A
Alain Sewer
Researcher at University of Basel
Publications - 67
Citations - 7184
Alain Sewer is an academic researcher from University of Basel. The author has contributed to research in topics: Biological network & Systems biology. The author has an hindex of 24, co-authored 65 publications receiving 6730 citations. Previous affiliations of Alain Sewer include Swiss Institute of Bioinformatics & Friedrich Miescher Institute for Biomedical Research.
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A mammalian microRNA expression atlas based on small RNA library sequencing.
Pablo Landgraf,Mirabela Rusu,Robert L. Sheridan,Alain Sewer,Alain Sewer,Nicola Iovino,Alexei A. Aravin,Sébastien Pfeffer,Amanda J. Rice,Alice O. Kamphorst,Markus Landthaler,Carolina Lin,Nicholas D. Socci,Leandro C. Hermida,Valerio Fulci,Sabina Chiaretti,Robin Foà,Julia Schliwka,Uta Fuchs,Astrid Novosel,Roman-Ulrich Müller,Roman-Ulrich Müller,Bernhard Schermer,Ute Bissels,Jason M. Inman,Quang Phan,Minchen Chien,David B. Weir,Ruchi Choksi,Gabriella De Vita,Daniela Frezzetti,Hans Ingo Trompeter,Veit Hornung,Grace Teng,Gunther Hartmann,Miklós Palkovits,Roberto Di Lauro,Peter Wernet,Giuseppe Macino,Charles E. Rogler,James W. Nagle,Jingyue Ju,F. Nina Papavasiliou,Thomas Benzing,Peter Lichter,Wayne Tam,Michael J. Brownstein,Andreas Bosio,Arndt Borkhardt,James J. Russo,Chris Sander,Mihaela Zavolan,Mihaela Zavolan,Thomas Tuschl +53 more
TL;DR: A relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues.
Journal ArticleDOI
Identification of microRNAs of the herpesvirus family
Sébastien Pfeffer,Alain Sewer,Mariana Lagos-Quintana,Robert L. Sheridan,Chris Sander,Friedrich A. Grässer,Linda F. van Dyk,C. Kiong Ho,C. Kiong Ho,Stewart Shuman,Minchen Chien,James J. Russo,Jingyue Ju,Glenn Randall,Brett D. Lindenbach,Charles M. Rice,Viviana Simon,David D. Ho,Mihaela Zavolan,Thomas Tuschl +19 more
TL;DR: To identify other miRNA genes in pathogenic viruses, a new miRNA gene prediction method with small-RNA cloning from several virus-infected cell types was combined and predicted miRNAs in several large DNA viruses.
Journal ArticleDOI
Identification of clustered microRNAs using an ab initio prediction method
Alain Sewer,Nicodeme Paul,Pablo Landgraf,Alexei A. Aravin,Sébastien Pfeffer,Sébastien Pfeffer,Michael J. Brownstein,Thomas Tuschl,Erik van Nimwegen,Mihaela Zavolan +9 more
TL;DR: This work describes a computational method for miRNA prediction and the results of its application to the discovery of novel mammalian miRNAs, and shows that although the overall miRNA content in the observed clusters is very similar across the three considered species, the internal organization of the clusters changes in evolution.
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Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells
Daniela Schmitter,Jody Filkowski,Alain Sewer,Ramesh S. Pillai,Edward J. Oakeley,Mihaela Zavolan,Petr Svoboda,Witold Filipowicz +7 more
TL;DR: The data suggest that, independent of the effect on translation, miRNAs affect levels of a few hundred mRNAs in HEK293 cells, and there is no evidence, at the mRNA level, for activation of silenced genes.
Journal ArticleDOI
Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers
Carole Mathis,Carine Poussin,Dirk Weisensee,Stephan Gebel,Arnd Hengstermann,Alain Sewer,Vincenzo Belcastro,Yang Xiang,Sam Ansari,Sandra Wagner,Julia Hoeng,Manuel C. Peitsch +11 more
TL;DR: A similar biological perturbation than the one observed in vivo in smokers' airway epithelium could be induced after a single CS exposure of a human organotypic bronchial epithelia-like tissue culture.