D
Dita Kasparova
Researcher at Charles University in Prague
Publications - 15
Citations - 181
Dita Kasparova is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Hypoxia (medical) & Hexokinase. The author has an hindex of 8, co-authored 15 publications receiving 148 citations. Previous affiliations of Dita Kasparova include Academy of Sciences of the Czech Republic.
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Journal ArticleDOI
Chronic Hypoxia Enhances Expression and Activity of Mitochondrial Creatine Kinase and Hexokinase in the Rat Ventricular Myocardium
Petra Waskova-Arnostova,Dita Kasparova,Barbara Elsnicova,Jiri Novotny,Jan Neckar,Frantisek Kolar,Jitka Zurmanova +6 more
TL;DR: Up-regulation of mtCKs and HK isoforms may stimulate the respiratory chain and help to maintain energy homeostasis of chronically hypoxic myocardium and prevent oxidative stress.
Journal ArticleDOI
Right-To-Left Ventricular Differences in the Expression of Mitochondrial Hexokinase and Phosphorylation of Akt
Petra Waskova-Arnostova,Barbara Elsnicova,Dita Kasparova,Ondrej Sebesta,Jiri Novotny,Jan Neckar,Frantisek Kolar,Jitka Zurmanova +7 more
TL;DR: The results suggest that the RV has a higher activity of aerobic glycolytic metabolism and may be able to respond faster and more powerfully to stressful stimuli than the LV.
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Altered thyroid status affects myocardial expression of connexin-43 and susceptibility of rat heart to malignant arrhythmias that can be partially normalized by red palm oil intake
Barbara Szeiffova Bacova,Csilla Vinczenzová,Jitka Žurmanová,Dita Kasparova,Dita Kasparova,Vladimir Knezl,Tamara Egan Beňová,Stanislav Pavelka,Tomáš Soukup,Narcisa Tribulova +9 more
TL;DR: There is an inverse relationship between myocardial expression of Cx43, including its functional phosphorylated forms, and susceptibility of male rat hearts to VF in condition of altered thyroid status, which partly ameliorated adverse changes caused by excess of thyroid hormones.
Journal ArticleDOI
Cardioprotective adaptation of rats to intermittent hypobaric hypoxia is accompanied by the increased association of hexokinase with mitochondria
Petra Waskova-Arnostova,Barbara Elsnicova,Dita Kasparova,Daniela Hornikova,Frantisek Kolar,Jiri Novotny,Jitka Zurmanova +6 more
TL;DR: It is suggested that Hexokinase (HK) may contribute to the cardioprotective phenotype induced by adaptation to severe intermittent hypobaric hypoxia.
Journal ArticleDOI
Cardioprotective and nonprotective regimens of chronic hypoxia diversely affect the myocardial antioxidant systems.
Dita Kasparova,Jan Neckar,Ludmila Dabrowská,Jiri Novotny,Jaroslav Mraz,Frantisek Kolar,Jitka Zurmanova +6 more
TL;DR: The results suggest that the increased mitochondrial antioxidant defense plays an important role in cardioprotection afforded by chronic hypoxia.