F
Frantisek Kolar
Researcher at Academy of Sciences of the Czech Republic
Publications - 120
Citations - 2468
Frantisek Kolar is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Hypoxia (medical) & Ischemia. The author has an hindex of 27, co-authored 111 publications receiving 2188 citations. Previous affiliations of Frantisek Kolar include Slovak Academy of Sciences.
Papers
More filters
Journal ArticleDOI
Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.
Martina Bajzikova,Martina Bajzikova,Jaromira Kovarova,Ana R Coelho,Ana R Coelho,Stepana Boukalova,Sehyun Oh,Katerina Rohlenova,David Svec,Sona Hubackova,Berwini Endaya,Kristyna Judasova,Ayenachew Bezawork-Geleta,Katarina Kluckova,Laurent Chatre,Laurent Chatre,Renata Zobalova,Anna Novakova,Katerina Vanova,Zuzana Ezrova,Zuzana Ezrova,Ghassan J. Maghzal,Ghassan J. Maghzal,Silvia Magalhaes Novais,Silvia Magalhaes Novais,Marie Olšinová,Linda Krobova,Yong Jin An,Eliska Davidova,Eliska Davidova,Zuzana Nahacka,Margarita Sobol,Teresa Cunha-Oliveira,Cristian Sandoval-Acuña,Hynek Strnad,Tongchuan Zhang,Thanh Huynh,Teresa L. Serafim,Pavel Hozák,Vilma A. Sardão,Werner J.H. Koopman,Miria Ricchetti,Miria Ricchetti,Paulo J. Oliveira,Frantisek Kolar,Mikael Kubista,Jaroslav Truksa,Katerina Dvorakova-Hortova,Katerina Dvorakova-Hortova,Karel Pacak,Robert Gürlich,Roland Stocker,Roland Stocker,Yaoqi Zhou,Michael V. Berridge,Sunghyouk Park,Lan-Feng Dong,Jakub Rohlena,Jiri Neuzil,Jiri Neuzil +59 more
TL;DR: It is shown that pyrimidine biosynthesis dependent on respiration-linked dihydroorotate dehydrogenase (DHODH) is required to overcome cell-cycle arrest, while mitochondrial ATP generation is dispensable for tumorigenesis, pointing to inhibitors of DHODH as potential anti-cancer agents.
Journal ArticleDOI
Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
Chris McDermott-Roe,Junmei Ye,Rizwan Ahmed,Xi-Ming Sun,Anna Serafín,James S. Ware,Leonardo Bottolo,Phil Muckett,Xavier Cañas,Jisheng Zhang,Glenn C. Rowe,Rachel Buchan,Han Lu,Adam Braithwaite,Massimiliano Mancini,David Hauton,Ramon Martí,Elena García-Arumí,Norbert Hubner,Norbert Hubner,Howard J. Jacob,Tadao Serikawa,Vaclav Zidek,Frantisek Papousek,Frantisek Kolar,Maria Cardona,Marisol Ruiz-Meana,David Garcia-Dorado,Joan X. Comella,Leanne E. Felkin,Paul J.R. Barton,Zoltan Arany,Michal Pravenec,Enrico Petretto,Daniel Sanchis,Stuart A. Cook +35 more
TL;DR: This study has further established the link between mitochondrial dysfunction, reactive oxygen species and heart disease and has uncovered a role for Endog in maladaptive cardiac hypertrophy.
Journal Article
Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia.
Frantisek Kolar,Ostádal B +1 more
TL;DR: This review summarizes current limited evidence for the involvement of ATP-sensitive potassium channels, reactive oxygen species, nitric oxide and various protein kinases in cardioprotective effects of chronic hypoxia.
Journal ArticleDOI
Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats
Jan Neckar,Ondrej Szárszoi,Lukás Koten,Frantisek Papousek,Bohuslav Ostadal,Gary J. Grover,Frantisek Kolar +6 more
TL;DR: The results suggest that opening of mitochondrial K(ATP) channels is involved in the cardioprotective mechanism conferred by long-term adaptation to intermittent high altitude hypoxia.
Journal ArticleDOI
Reciprocal changes in the postnatal expression of the sarcolemmal Na+-Ca2+-exchanger and SERCA2 in rat heart
TL;DR: The inversely related changes in the post-natal expression and function of the Na(+)-Ca2+ exchanger and SR Ca(2+)-ATPase suggest a coordinated control at the pretranslational level of the cellular Ca2+ transport processes mediated by the two membrane proteins.