D
Ditlev E. Brodersen
Researcher at Aarhus University
Publications - 88
Citations - 9982
Ditlev E. Brodersen is an academic researcher from Aarhus University. The author has contributed to research in topics: RNA & Antitoxin. The author has an hindex of 33, co-authored 82 publications receiving 9277 citations. Previous affiliations of Ditlev E. Brodersen include La Trobe University & Laboratory of Molecular Biology.
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Journal ArticleDOI
Shape can be seductive.
TL;DR: Because some translation factors mimic the shape of tRNA, they were thought to bind the ribosome in a similar manner, and work suggests that this idea of molecular mimicry needs to be reassessed.
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Saccharomyces cerevisiae Ngl3p is an active 3′–5′ exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases
Ane Feddersen,Emil Dedic,Esben G. Poulsen,Manfred Schmid,Lan Bich Van,Torben Heick Jensen,Ditlev E. Brodersen +6 more
TL;DR: It is shown using in vitro deadenylation assays on defined RNA species mimicking poly-A containing mRNAs that yeast Ngl3p is a functional 3′–5′ exonuclease most active at slightly acidic conditions, and it is suggested that Ngl2p is naturally involved in processing of poly-adenylated RNA.
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Applications of single‐wavelength anomalous dispersion at high and atomic resolution. Corrigendum
Ditlev E. Brodersen,E. de la Fortelle,C. Vonrhein,Gérard Bricogne,Jens Nyborg,Morten Kjeldgaard +5 more
TL;DR: It is shown that the structure of psoriasin can be determined from native data extending to 2.0 A alone by exploiting the minute anomalous signal from a bound zinc ion.
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Mimer: an automated spreadsheet-based crystallization screening system.
TL;DR: A simple low-cost alternative to large commercial systems for preparing macromolecular crystallization conditions is described, using an intuitive spreadsheet-based approach that incorporates the automatic design of custom crystallization screens via the incomplete-factorial and grid-screen approaches.
Journal ArticleDOI
Phasing the 30S ribosomal subunit structure
Ditlev E. Brodersen,William M. Clemons,Andrew P. Carter,Brian T. Wimberly,Venki Ramakrishnan +4 more
TL;DR: It is shown that the anomalous signal collected from heavy-atom compounds bound to the RNA is both necessary and sufficient for ab initio structure determination at high resolution.