Dittakavi S. R. Sarma

TL;DR: A new approach to the sequential analysis of carcinogenesis in vivo is developed that delineates the first few steps in the process and is a quantitative assay for initiation of liver cancer, to investigate whether cell replication exerts its first effect on initiation or on some later step in the carcinogenic process.

TL;DR: Using the Caco-2 cell line, a well established model of colon cancer cells, data show that butyrate induced apoptosis (maximum 79%) is mediated via activation of the caspase-cascade and the mitochondrial bcl-pathway.

TL;DR: In this paper, the relative stability of selected cis-isomers of Lycopene with respect to the all-trans isomer, was studied and the optimized molecular conformational study structures indicated that the central conjugated part of every lycopene isomer is planar and the two tail ends of the molecules, each containing three single C-C bonds, avoid coplanarity.

TL;DR: The results are in agreement with the hypothesis that selective proliferation of transplanted hepatocytes in retrorsine-treated animals is dependent, at least in part, on the persistent cell cycle block imposed by the alkaloid on endogenous parenchymal cells.

TL;DR: It is suggested that depending on the nature of the proliferative stimulus, an increased expression of c‐fos, c‐jun and c‐myc may not be necessary for in vivo induction of liver cell proliferation.