E
Ernest G. Seidman
Researcher at McGill University
Publications - 331
Citations - 16383
Ernest G. Seidman is an academic researcher from McGill University. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 64, co-authored 330 publications receiving 15209 citations. Previous affiliations of Ernest G. Seidman include Montreal Children's Hospital & Université de Montréal.
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Journal ArticleDOI
Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
Ivor D. Hill,Martha H. Dirks,Gregory S. Liptak,Richard B. Colletti,Alessio Fasano,Stefano Guandalini,Edward J. Hoffenberg,Karoly Horvath,Joseph A. Murray,Mitchell Pivor,Ernest G. Seidman +10 more
TL;DR: It is recommended that children and adolescents with symptoms of celiac disease or an increased risk for Celiac disease have a blood test for antibody to tissue transglutaminase (TTG), and that those with an elevated TTG be referred to a pediatric gastroenterologist for an intestinal biopsy and treated with a strict gluten-free diet.
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Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
Marla Dubinsky,Stéphanie Lamothe,Huiying Yang,Stephan R. Targan,Daniel Sinnett,Yves Théorêt,Ernest G. Seidman +6 more
TL;DR: 6-MP metabolite levels and TPMT genotyping may assist clinicians in optimizing therapeutic response to 6-MP and identifying individuals at increased risk for drug-induced toxicity.
Journal ArticleDOI
6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.
Marla Dubinsky,Huiying Yang,Philip V. Hassard,Ernest G. Seidman,Lori Y. Kam,Maria T. Abreu,Stephan R. Targan,Eric A. Vasiliauskas +7 more
TL;DR: Serial metabolite monitoring identifies a novel phenotype of IBD patients resistant to 6-MP/AZA therapy biochemically characterized by suboptimal 6-TGN and preferential 6-MMPR production upon dose escalation.
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Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease
Tian-Tian Wang,Basel Dabbas,David Laperrière,Ari J. Bitton,Hafid Soualhine,Luz E. Tavera-Mendoza,Serge Dionne,Marc J. Servant,Alain Bitton,Ernest G. Seidman,Sylvie Mader,Marcel A. Behr,John H. White +12 more
TL;DR: Hormonal vitamin D, 1,25-dihydroxyvitamin D3, robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1 gene and protein in primary human monocytic and epithelial cells, providing strong molecular links between vitamin D deficiency and the genetics of Crohn disease, a chronic incurable inflammatory bowel condition.
Journal ArticleDOI
Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change
Ian M. Gralnek,R. Defranchis,Ernest G. Seidman,Jonathan A. Leighton,Peter Legnani,Basil S. Lewis +5 more
TL;DR: This manuscript documents the development of a validated index for capsule endoscopy findings and states that this index is likely to be applicable to small bowel mucosal inflammatory change.