Do Youn Jun

TL;DR: It is demonstrated that the apoptotic effect of AUR on Jurkat T cells was exerted by the ER stress-mediated activation of caspase-8, and the subsequent induction of mitochondria-dependent or -independent activation ofcaspase cascade, which could be suppressed by Bcl-xL.

TL;DR: The results demonstrate that although two isoforms of human PSAT can be produced by alternative splicing, PSAT beta rather than PSAT alpha is the physiologically functional enzyme required for the phosphorylated pathway, and indicate that the humanPSAT gene is regulated depending on tissue specificity as well as cellular proliferation status with a maximum level expression in the S-phase.

TL;DR: It is demonstrated that the human 3-PGDH gene is regulated at the transcriptional level depending on tissue specificty and cellular proliferative status, and its transcriptional regulation mechanism may be a useful target for diagnosis and therapy of cancer.

TL;DR: It is demonstrated that mollugin-induced cytotoxicity in Jurkat T cells was mainly attributable to apoptosis provoked via endoplasmic reticulum (ER) stress-mediated activation of JNK and caspase-12, and subsequent mitochondria-dependent activation of caspasing-9 and -3, which could be regulated by Bcl-xL.

TL;DR: In conclusion, PHGDH, PDK1, and PSAT were significantly increased in colonic TT compared with pNT, and the prognostic implication of these enzymes needs to be further investigated.