D
Doina Ganea
Researcher at Temple University
Publications - 152
Citations - 10552
Doina Ganea is an academic researcher from Temple University. The author has contributed to research in topics: Vasoactive intestinal peptide & Immune system. The author has an hindex of 67, co-authored 152 publications receiving 9947 citations. Previous affiliations of Doina Ganea include Rutgers University & Indiana University.
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Journal ArticleDOI
The Significance of Vasoactive Intestinal Peptide in Immunomodulation
TL;DR: Recognition of the central functions VIP plays in cellular processes is focusing attention on this “very important peptide” as exciting new candidates for therapeutic intervention and drug development.
Journal ArticleDOI
The Proinflammatory Effect of Prostaglandin E2 in Experimental Inflammatory Bowel Disease Is Mediated through the IL-23→IL-17 Axis
Amir F. Sheibanie,Jui-Hung Yen,Jui-Hung Yen,Tanzilya Khayrullina,Tanzilya Khayrullina,Frances A. Emig,Ming Zhang,Ronald F. Tuma,Doina Ganea +8 more
TL;DR: It is proposed that high levels of PGE2 exacerbate the inflammatory process in inflammatory bowel disease through the preferential expression and release of DC-derived IL-23 and the subsequent support of the autoreactive/inflammatory Th17 phenotype.
Journal Article
Vasoactive Intestinal Peptide (VIP) and Pituitary Adenylate Cyclase-Activation Polypeptide (PACAP) Protect Mice from Lethal Endotoxemia Through the Inhibition of TNF-α and IL-6
Mario Delgado,Mario Delgado,Carmen Martínez,David Pozo,Juan R. Calvo,Javier Leceta,Doina Ganea,Rosa P. Gomariz +7 more
TL;DR: The neuropeptides VIP/PACAP protect from the lethal effect of high endotoxemia, presumably by down-regulating TNF-α and IL-6 production, and may offer an alternative in the treatment of human septic shock syndrome.
Journal Article
Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Enhance IL-10 Production by Murine Macrophages: In Vitro and In Vivo Studies
TL;DR: The stimulation of IL-10 production in activated macrophages represents a novel anti-inflammatory activity of VIP and PACAP, which presumably acts in vivo in conjunction with the inhibition of proinflammatory cytokines such as IL-6 and TNF-alpha to reduce the magnitude of the immune response.
Journal ArticleDOI
Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells
TL;DR: The results indicate that PGE2 increases the production of functional IL‐23 from immature BM‐DCs in a time‐ and dose‐dependent manner, and suggest an additional mechanism for its pro‐ inflammatory role, particularly significant for autoimmune diseases, such as rheumatoid arthritis.