Dominic P. Williams

TL;DR: The HRD score appears capable of detecting homologous recombination defects regardless of aetiology or mechanism, which could facilitate the use of PARP inhibitors and platinum in breast, ovarian, and other cancers.

TL;DR: This review summarizes the evidence for reactive metabolite formation from hepatotoxic drugs, such as acetaminophen, tamoxifen, diclofenac, and troglitazone, and the current hypotheses of how this leads to liver injury and indicates that the toxicity of reactive metabolites may be mediated by noncovalent binding mechanisms, which may also have profound effects on normal liver physiology.

TL;DR: An assessment of the current approaches used for the evaluation of chemically reactive metabolites and how these approaches are being used within the pharmaceutical industry to assess and minimize the potential of drug candidates to cause toxicity is presented.

TL;DR: K18 and HMGB1 represent blood-based tools to investigate the cell death balance clinical APAP hepatotoxicity and were identified and quantified by novel LC-MS/MS assays in APAP overdose patients and were associated with worse prognosis.

TL;DR: A rat, dog, and human Liver-Chip designed using microengineered Organs-on-Chips technology recapitulates species-specific drug toxicities and may provide a useful platform for prediction of liver toxicity and inform human relevance of liver toxicities detected in animal studies to better determine safety and human risk.