Showing papers in "Journal of Hepatology in 2012"

TL;DR: A fresh look at the fundamentals of liver regeneration in light of recent technical innovations is taken, and it is demonstrated that there are three peaks of DNA synthesis after PH, initially in zone 1, then in the mid-lobule, and 15% of pre-existing hepatocytes never divide after PH.

TL;DR: All data since 1968 are considered to show the evolu-tion of results of LT in Europe since its initial development and to demonstrate the reliability of ELTR data.

TL;DR: Current evidence as it pertains to the epidemiology, pathogenesis, and prevention of NAFLD-associated HCC, including metformin and PPAR gamma agonists, is summarized.

TL;DR: Novel findings related to nuclear receptor signaling in hepatic lipid and glucose uptake, storage and metabolism in the clinical context of non-alcoholic fatty liver disease, liver regeneration, and cancer are focused on.

TL;DR: The SHARP trial as discussed by the authors showed that sorafenib consistently improved median OS and DCR compared with placebo in patients with advanced HCC, irrespective of disease etiology, baseline tumor burden, performance status, tumor stage and prior therapy.

TL;DR: In this paper, the authors focus on the current understanding of acute-on-chronic liver failure from the clinical, prognostic and pathophysiological perspectives and indicate potential biomarkers and therapeutic targets for intervention.

TL;DR: Percutaneous RFA is more likely to be incomplete for the treatment of small HCCs located at specific sites of the liver, and open or laparoscopic surgery may be the better choice in patients with small hepatocellular carcinomas.

TL;DR: The “KASL Clinical Practice Guidelines: Management of Alcoholic Liver Disease” are developed, based on a systematic approach to reflect evidence-based medicine and expert opinion in internal medicine and psychiatry, with the aim of setting clinical practice guidelines for the management of ALD and improving public health in Korea.

TL;DR: Today curative therapies can improve survival in patients diagnosed at an early HCC stage and offer a potential long-term cure and those diagnosed at advanced stage benefit from sorafenib, a multikinase inhibitor with antiangiogenic and antiproliferative effects.

TL;DR: Incidence and prevalence rates of both PSC and PBC vary widely and seem to be increasing, therefore large population-based studies combining meticulous case-finding and case-ascertainment strategies are necessary.

TL;DR: The pooled data suggest that omega-3 PUFA supplementation may decrease liver fat, however, the optimal dose is currently not known.

TL;DR: Lifestyle modifications leading to weight reduction and/or increased physical activity consistently reduced liver fat and improved glucose control/insulin sensitivity and limited data suggest that lifestyle interventions may hold benefits for histopathology.

TL;DR: Recent advances in elucidation of cellular and molecular alterations and signaling pathways associated with obesity and liver inflammation and their contribution to hepatocarcinogenesis are reviewed and discussed.

TL;DR: These data validate the safety of DEB-TACE and show that the survival expectancy applying current selection criteria and technique is better than that previously reported.

TL;DR: The importance of inflammasome activation in various forms of liver diseases in relation to liver damage, steatosis, inflammation and fibrosis is discussed in this review.

TL;DR: Cirrhosis, chronic hepatitis B and C, alcohol use, diabetes, and obesity are major risk factors for intrahepatic cholangiocarcinoma and a common pathogenesis of primary intra hepatic epithelial cancers is suggested.

TL;DR: In this article, the authors evaluated the efficacy of aerobic exercise and progressive resistance training for the modulation of liver fat and alanine aminotransferase (ALT) levels in adults.

TL;DR: An up-to-date review of the currently available clinical data is provided and technical caveats that highlight the need for caution in establishing a new dogma that human liver fibrosis is reversible are considered.

TL;DR: Gadolinium ethoxybenzyl dimeglumine-enhanced magnetic resonance imaging may provide quantitative assessment regarding liver perfusion and hepatocyte function in diffuse liver diseases and improve the detection and characterization of focal liver lesions and diffuse liver disease.

TL;DR: A strategy of careful restriction of prophylactic antibiotics to the high-risk populations could reduce the spread of multidrug resistant bacteria.

TL;DR: Plasma microRNA-21 level is a promising biochemical marker for hepatocellular carcinoma, superior to α-fetoprotein and improved for the combination of micro RNA-21 and α- Fetoprotein.

TL;DR: The demonstration of partly inhibition of in vitro HSC activation after treatment with an autophagy inhibitor unveils a potential new therapeutic strategy for liver fibrosis.

TL;DR: K18 and HMGB1 represent blood-based tools to investigate the cell death balance clinical APAP hepatotoxicity and were identified and quantified by novel LC-MS/MS assays in APAP overdose patients and were associated with worse prognosis.

TL;DR: Transient elastography (TE) is a novel non invasive technology that allows measuring liver stiffness and that has gained popularity over the past few years, suggesting that it could be an interesting tool for the non invasive evaluation of portal hypertension.

TL;DR: The proof of concept that IFN-free regimens may lead to HCV eradication has recently been brought, however, new drugs may be associated with troublesome side effects and drugdrug interactions, and the ideal IFn-free DAA combination remains to be found.

TL;DR: For HCC patients in BCLC very early/early stage, there was no significant difference in OS between SR and RFA, however, SR yielded better DFS than RFA in DFS.

TL;DR: In this paper, the authors calculated the range of disease severity of non-alcoholic fatty liver disease (NAFLD) in a primary care setting and found that NAFLD is the commonest cause of incidental LFT abnormalities in primary care.

TL;DR: With a number of clinical trials underway, the available evidence shows that radioembolization adds a significant value to the therapeutic weaponry against HCC of tertiary care centers dealing with this major cancer problem.

TL;DR: Acute liver injury is associated with an early onset of increased intestinal permeability and bacterial translocation that precede changes in the microbiome, and the enteric microbiome differs with respect to the etiology of liver disease.

TL;DR: Idiosyncratic liver injury associated with statins is rare but can be severe, and after recovery, a similar pattern of liver injury can be reproduced on re-exposure.