Dominik R. Buell

TL;DR: The results not only enlighten the path of NPS in the brain, but also establish a non-invasive method for NPS administration in mice, thus strongly encouraging translation into a novel therapeutic approach for pathological anxiety in humans.

TL;DR: HPA-axis reactivity endophenotypes are identified and characterized for the first time to offer an explanation for the inconsistent reports on HPA- axis function in PTSD and suggest that most likely other factors play a decisive role in determination of PTSD core symptom severity.

TL;DR: It is suggested that traumatic stress and fluoxetine interact to cause distinct alterations in the mouse PFC miRNA signature in the long-term, as well as a significant reduction in mmu-miR-1971 expression.

TL;DR: This study demonstrates for the first time that a loss of hippocampal synaptic proteins is associated with a PTSD-like syndrome in mice, and demonstrates that treatment with the serotonin reuptake inhibitor (SSRI) fluoxetine is able to counteract both the PTSD- like syndrome and the posttraumatic synaptic protein loss.

TL;DR: The first review on ncRNAs in PTSD is conducted and it is suggested that mir-132, which has been found to be regulated in three of the here included studies, as well as miRNAs with an already established role in Alzheimer's disease (AD) seem to be particularly promising candidates for future miRNA studies in PTSD.