U
Ulrike Schmidt
Researcher at Max Planck Society
Publications - 53
Citations - 2457
Ulrike Schmidt is an academic researcher from Max Planck Society. The author has contributed to research in topics: Glucocorticoid receptor & Receptor. The author has an hindex of 24, co-authored 53 publications receiving 2137 citations. Previous affiliations of Ulrike Schmidt include Maastricht University.
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Journal ArticleDOI
FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells
Gabriela M. Wochnik,Joëlle Rüegg,G. Alexander Abel,Ulrike Schmidt,Florian Holsboer,Theo Rein +5 more
TL;DR: The mechanisms of the regulatory system FKBP51/FKBP52 discovered in yeast also operate in mammals to modulate hormone binding of the receptor and differential regulation of dynein association and nuclear translocation contributes to the effects of the two immunophilins on the glucocorticoid receptor in mammals.
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FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior
Chadi Touma,Nils C. Gassen,Leonie Herrmann,Joyce Cheung-Flynn,D. Büll,Irina A. Ionescu,J. M. Heinzmann,Alana Knapman,Anna Siebertz,Anna-Mareike Depping,Jakob Hartmann,Felix Hausch,Mathias V. Schmidt,Florian Holsboer,Marcus Ising,Marc B. Cox,Ulrike Schmidt,Theo Rein +17 more
TL;DR: This study in mice and humans presents FKBP5 as a decisive factor for the physiological stress response, shaping neuroendocrine reactivity as well as coping behavior, lending strong support to the concept emerging from human studies of FK BP5 as important factor governing gene-environment interactions relevant for the etiology of affective disorders.
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The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress.
Jakob Hartmann,Klaus V. Wagner,C. Liebl,Sebastian H. Scharf,Xiao-Dong Wang,Miriam Wolf,Felix Hausch,Theo Rein,Ulrike Schmidt,Chadi Touma,Joyce Cheung-Flynn,Marc B. Cox,David F. Smith,Florian Holsboer,Marianne B. Müller,Mathias V. Schmidt +15 more
TL;DR: Results suggest an enhanced negative glucocorticoid feedback within the HPA axis of 51KO mice, possibly modulated by an increased sensitivity of the GR.
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Reduced hippocampus volume in the mouse model of Posttraumatic Stress Disorder.
Yulia Golub,Sebastian F. Kaltwasser,Christoph P. Mauch,Leonie Herrmann,Ulrike Schmidt,F. Holsboer,Michael Czisch,Carsten T. Wotjak +7 more
TL;DR: It is demonstrated that traumatic experience in mice causes a reduction in HPC and central amygdala volume possibly due to a shrinkage of axonal protrusions and enriched housing decreased the intensity of trauma-associated contextual fear, independently of whether it was provided before or after the shock.
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Posttraumatic Growth in Populations with Posttraumatic Stress Disorder—A Systematic Review on Growth‐Related Psychological Constructs and Biological Variables
TL;DR: Results indicate that trauma survivors with PTSD exhibit more PTG than those without PTSD and that PTG can be intensified during the therapeutic process, but it remains unclear whether PTG is a desirable outcome of PTSD therapy.