J
Julien Dine
Researcher at Max Planck Society
Publications - 26
Citations - 890
Julien Dine is an academic researcher from Max Planck Society. The author has contributed to research in topics: Optogenetics & Medicine. The author has an hindex of 14, co-authored 21 publications receiving 632 citations. Previous affiliations of Julien Dine include Weizmann Institute of Science & French Institute of Health and Medical Research.
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Journal ArticleDOI
Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood
Nina Dedic,Max L. Pöhlmann,Julia Richter,Divya Mehta,D Czamara,Michael W. Metzger,Julien Dine,Benedikt T. Bedenk,Jakob Hartmann,Jakob Hartmann,Klaus V. Wagner,Angela Jurik,Lynn M. Almli,Adriana Lori,Sven Moosmang,Franz Hofmann,Carsten T. Wotjak,Gerhard Rammes,Matthias Eder,Alon Chen,Alon Chen,Kerry J. Ressler,Kerry J. Ressler,Wolfgang Wurst,Mathias V. Schmidt,Elisabeth B. Binder,Jan M. Deussing +26 more
TL;DR: It is shown that embryonic deletion of Cacna1c in forebrain glutamatergic neurons promotes the manifestation of endophenotypes related to psychiatric disorders including cognitive decline, impaired synaptic plasticity, reduced sociability, hyperactivity and increased anxiety.
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Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.
Nina Dedic,Claudia Kühne,Mira Jakovcevski,Jakob Hartmann,Jakob Hartmann,Andreas Genewsky,Karina S. Gomes,Elmira Anderzhanova,Max L. Pöhlmann,Simon Chang,Adam Kolarz,Annette M. Vogl,Julien Dine,Michael W. Metzger,Bianca Schmid,Rafael Carvalho Almada,Kerry J. Ressler,Carsten T. Wotjak,Valery Grinevich,Alon Chen,Mathias V. Schmidt,Wolfgang Wurst,Wolfgang Wurst,Damian Refojo,Jan M. Deussing +24 more
TL;DR: A new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion are described.
Journal ArticleDOI
Intranasally Administered Neuropeptide S (NPS) Exerts Anxiolytic Effects Following Internalization Into NPS Receptor-Expressing Neurons
Irina A. Ionescu,Julien Dine,Yi-Chun Yen,Dominik R. Buell,Leonie Herrmann,Florian Holsboer,Matthias Eder,Rainer Landgraf,Ulrike Schmidt +8 more
TL;DR: The results not only enlighten the path of NPS in the brain, but also establish a non-invasive method for NPS administration in mice, thus strongly encouraging translation into a novel therapeutic approach for pathological anxiety in humans.
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Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics
Yair Shemesh,Yair Shemesh,Oren Forkosh,Oren Forkosh,Mathias Mahn,Sergey Anpilov,Sergey Anpilov,Yehezkel Sztainberg,Sharon Manashirov,Sharon Manashirov,Tamar Shlapobersky,Tamar Shlapobersky,Evan Elliott,Laure Tabouy,Gili Ezra,Gili Ezra,Elaine S Adler,Elaine S Adler,Yair J. Ben-Efraim,Yair J. Ben-Efraim,Shosh Gil,Shosh Gil,Yael Kuperman,Sharon Haramati,Julien Dine,Matthias Eder,Jan M. Deussing,Elad Schneidman,Ofer Yizhar,Alon Chen,Alon Chen +30 more
TL;DR: It is shown that mice deficient in CRF-R2 or Ucn3 exhibit abnormally low preference for novel conspecifics, and these findings collectively suggest that the MeA UCN3–CRF- R2 system modulates the ability of mice to cope with social challenges.
Journal ArticleDOI
CRF receptor type 2 neurons in the posterior bed nucleus of the stria terminalis critically contribute to stress recovery
Marloes J. A. G. Henckens,Yoav Printz,U. Shamgar,Julien Dine,Maya Lebow,Yonat Drori,Claudia Kuehne,Adam Kolarz,Matthias Eder,Jan M. Deussing,Nicholas J. Justice,Ofer Yizhar,Alon Chen +12 more
TL;DR: It is found that CRFR2-expressing neurons within the pBNST send dense inhibitory projections to other stress-related brain regions, implicating a prominent role of these neurons in orchestrating the neuroendocrine, autonomic and behavioral response to stressful situations.