D
Dominique Cross
Researcher at Children's Hospital of Philadelphia
Publications - 4
Citations - 1524
Dominique Cross is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Randomized controlled trial & Cataracts. The author has an hindex of 3, co-authored 4 publications receiving 1048 citations.
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Journal ArticleDOI
Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial
Stephen R. Russell,Jean Bennett,Jennifer Wellman,Daniel C. Chung,Zi Fan Yu,Amy Tillman,Janet Wittes,Julie Pappas,Okan U. Elci,Sarah McCague,Dominique Cross,Kathleen A. Marshall,Jean Walshire,Taylor Kehoe,Hannah Reichert,Maria C. Davis,Leslie Raffini,Lindsey A. George,F. Parker Hudson,Laura E. Dingfield,Xiaosong Zhu,Julia A. Haller,Elliott H. Sohn,Vinit B. Mahajan,Wanda Pfeifer,Michelle T. Weckmann,Chris A. Johnson,Dina Y. Gewaily,Arlene V. Drack,Edwin M. Stone,Katie Wachtel,Francesca Simonelli,Bart P. Leroy,Bart P. Leroy,J. Fraser Wright,Katherine A. High,Albert M. Maguire +36 more
TL;DR: Voretigene neparvovec gene replacement improved functional vision in RPE65-mediated inherited retinal dystrophy previously medically untreatable.
Journal ArticleDOI
Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial
Jean Bennett,Jean Bennett,Jennifer Wellman,Kathleen A. Marshall,Sarah McCague,Manzar Ashtari,Manzar Ashtari,Julie DiStefano-Pappas,Okan U. Elci,Daniel C. Chung,Junwei Sun,Junwei Sun,J. Fraser Wright,Dominique Cross,Puya Aravand,Laura Cyckowski,Jeannette L. Bennicelli,Federico Mingozzi,Alberto Auricchio,Eric A. Pierce,Jason Ruggiero,Bart P. Leroy,Bart P. Leroy,Francesca Simonelli,Katherine A. High,Katherine A. High,Albert M. Maguire +26 more
TL;DR: To the knowledge, AAV2-hRPE65v2 is the first successful gene therapy administered to the contralateral eye and the results highlight the use of several outcome measures and help to delineate the variables that contribute to maximal benefit from gene augmentation therapy in this disease.
Journal ArticleDOI
Novel mobility test to assess functional vision in patients with inherited retinal dystrophies.
Daniel C. Chung,Sarah McCague,Zi-Fan Yu,Satha Thill,Julie DiStefano-Pappas,Jean Bennett,Jean Bennett,Dominique Cross,Kathleen A. Marshall,Jennifer Wellman,Katherine A. High +10 more
TL;DR: This novel endpoint tracks functional vision changes in patients with inherited retinal dystrophies (IRDs) over time and shows clear signs of improvement in some cases and decline in others.
Journal Article
Mobility testing validation study - Using a novel, standardized mobility test to evaluate functional vision in patients with inherited retinal degeneration
Sarah McCague,Jennifer Wellman,Fan-Fan Yu,Satha Thill,Julie DiStefano-Pappas,Jean Bennett,Dominique Cross,Kathleen A. Marshall,Katherine A. High,Daniel C. Chung +9 more