J
Janet Wittes
Researcher at National Institutes of Health
Publications - 164
Citations - 32510
Janet Wittes is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Clinical trial & Randomized controlled trial. The author has an hindex of 58, co-authored 150 publications receiving 29867 citations. Previous affiliations of Janet Wittes include United States Department of Agriculture & University of New South Wales.
Papers
More filters
Journal ArticleDOI
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
Journal ArticleDOI
Gemfibrozil for the Secondary Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol
Hanna Bloomfield Rubins,Sander J. Robins,Dorothea Collins,Carol L. Fye,James W. Anderson,Marshall B. Elam,Fred H. Faas,Esteban Linares,Ernst J. Schaefer,Gordon Schectman,Timothy J Wilt,Janet Wittes +11 more
TL;DR: Gemfibrozil therapy resulted in a significant reduction in the risk of major cardiovascular events in patients with coronary disease whose primary lipid abnormality was a low HDL cholesterol level, suggesting that the rate of coronary events is reduced by raising HDL cholesterol levels and lowering levels of triglycerides without lowering LDL cholesterol levels.
Journal ArticleDOI
Cardiovascular Risk Associated With Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention
Scott D. Solomon,John J.V. McMurray,Marc A. Pfeffer,Janet Wittes,Robert A. Fowler,Peter V. Finn,William F. Anderson,Ann G. Zauber,Ernest T. Hawk,Monica M. Bertagnolli +9 more
TL;DR: Celecoxib use was associated with a dose-related increase in the composite end point of death from cardiovascular causes, myocardial infarction, stroke, or heart failure, providing further evidence that the use of COX-2 inhibitors may increase the risk of serious cardiovascular events.
Journal ArticleDOI
Intensity of renal support in critically ill patients with acute kidney injury
Paul M. Palevsky,Jane Hongyuan Zhang,Theresa Z. O'Connor,Glenn M. Chertow,Susan T. Crowley,Devasmita Choudhury,Kevin W. Finkel,John A. Kellum,Emil P. Paganini,Roland M. H. Schein,Mark W. Smith,Kathleen M. Swanson,B. Taylor Thompson,Anitha Vijayan,Suzanne Watnick,Robert A. Star,Peter Peduzzi,E. Young,R. Fissel,W. Fissel,Uptal D. Patel,K. Belanger,A. Raine,N. Ricci,James B. Lohr,P. Arora,D. Cloen,D. Wassel,L. Yohe,J. Amanzadeh,J. Penfield,M. Hussain,R. Katneni,A. Sajgure,A. Swann,G. Dolson,V. Ramanathan,G. Tasby,Robert L. Bacallao,M. Jaradat,Kenneth Edward Graves,Q. Li,M. Krause,M. Shaver,M. Alam,K. Morris,T. Bland,E. Satter,Jeffrey A. Kraut,A. Felsenfeld,B. Levine,G. Nagami,B. Vaghaiwalla,J. Duffney,Joseph O. Moore,C. Cely,E. Jaimes,Daniel H. Kett,Andrew A. Quartin,M. Arcia,A. Barchi-Chung,Vecihi Batuman,A. Alper,A. Dreisbach,E. Simon,C. Kulivan,Nabeel Aslam,M.C. Ramkumar,E. Grum,P. Rogers,Steven D. Weisbord,C. Geffel,Ihab M. Wahba,Darren J. Kelly,J. Walczyk,George Feldman,A. Mogyorosi,G. Viol,M. Halverson,S. Schmid,H. Totten,Francis B. Gabbai,S. Mullaney,R. Smith,J. Dingsdale,S. Woods,Kirsten L. Johansen,David H. Lovett,Ann M. O’Hare,James T. McCarthy,C. Rosado-Rodriguez,A. Galera,G. Rodriguez-Vega,W. Rodriguez,C. Vilchez,B. Young,Dennis L. Andress,A. Lindner,G. Galvin,N. Gourley,Aldo J. Peixoto,M. Perkal,C. Joncas,Sevag Demirjian,J. Yared,R. Brienza,M. Garcia,T. Seifert,L. Sweeney,Hamid Rabb,Mohamed G. Atta,Roy G. Brower,M. Choi,Joseph A. Eustace,Paul J. Scheel,E. Heck,H. Rahman,John L. Niles,H. Bazari,K. Smirnakis,D. Steele,Ravi Thadhani,K. Laliberte,B. Leeman,C. McCarthy,M. Pescatore,Harold M. Szerlip,P. Fall,M. Jagadeesan,Laura L Mulloy,William D Paulson,J. White,N. Sickafoose,K. Cho,M. Gropper,K. Liu,Michael A. Matthay,K. Borovitz,M. Koenigsberg,S. Rodriguez,Gabriel Contreras,S. Cohn,J. Diego,C. Carvalho,D. Carvalho,M. Castro,C. de la Cuesta,I. Espinal,A. Hurtado,P. Oyuela,Mark Unruh,Renee Burr,Michael P. Donahoe,J. Marszalek,M. Shields,R. Venkataraman,J. Aubrecht,H. Sterling,L. Mandich,A. Shaw,J. Foringer,J. Samuels,B. Efron,Michael V. Rocco,E. Deterding,Shahriar Moossavi,C. Bethea,D. McBride,Stuart R. Warren,M. Kollef,K. Sambandam,E. Hammer,M. Hoffman,John B. Stokes,Alfred F. Connors,Harold I. Feldman,Joel W. Greer,G. G. Koch,Thomas E. Stewart,Janet Wittes,P. Overberger,S. Michler,Massimo Antonelli,K. Dellert,L. Durant,R. Franchini,A. Kossack,V. McBride,S. O'Neil,Taposh Roy,J. Russo,Joseph N. Vitale,Mike R. Sather,C. Fye,C. M. Haakenson,D. H. Krueger,J. Thornton,C. Dalzell,R. Horney,Andrew M. Siroka,P. Su,Mary Brophy,D. Humphries,D. Govan,Timothy J. O'Leary,G. D. Huang,John R. Feussner,Paul W. Eggers +207 more
TL;DR: Intensive renal support in critically ill patients with acute kidney injury did not decrease mortality, improve recovery of kidney function, or reduce the rate of nonrenal organ failure as compared with less-intensive therapy.
Journal ArticleDOI
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: Meta-analyses of individual participant data from randomised trials
Colin Baigent,Neeraj Bhala,Jonathan Emberson,A Merhi,S. Abramson,Nadir Arber,John A. Baron,Claire Bombardier,Christopher P. Cannon,Michael E. Farkouh,Garret A. FitzGerald,Paul E. Goss,Heather Halls,Ernest T. Hawk,Christopher J. Hawkey,C H Hennekens,Marc C. Hochberg,Lisa Holland,Patricia M. Kearney,Loren Laine,Angel Lanas,Peter Lance,Andreas Laupacis,Jim C. Oates,Carlo Patrono,Thomas J. Schnitzer,Scott D. Solomon,Peter Tugwell,Kate Wilson,Janet Wittes,O. Adelowo,P. Aisen,Abdulaziz A Al-Quorain,Roy D. Altman,George L. Bakris,H. Baumgartner,C. Bresee,M. Carducci,D. M. Chang,C. T. Chou,D. Clegg,M. Cudkowicz,L. Doody,Y. El Miedany,Claire Falandry,J. Farley,Leslie G. Ford,M. Garcia-Losa,M. Gonzalez-Ortiz,M. Haghighi,M. Hala,T. Iwama,Zrinka Jajić,David J. Kerr,H. S. Kim,C.-H. Köhne,B. K. Koo,Barbara K. Martin,Curtis L. Meinert,N. Muller,G. Myklebust,D. Neustadt,R. Omdal,S. Ozgocmen,A. Papas,Paola Patrignani,F. Pelliccia,V. Roy,I. Schlegelmilch,Asad Umar,O. Wahlstrom,F. Wollheim,S. Yocum,X. Y. Zhang,E. Hall,Patricia McGettigan,R Midgley,R. A. Moore,R. Philipson,Sean P. Curtis,Alise S. Reicin,John H. Bond,Ami R. Moore,M. Essex,J. Fabule,B. Morrison,Leslie Tive,Kelly Davies,F. Yau +88 more
TL;DR: Although NSAIDs increase vascular and gastrointestinal risks, the size of these risks can be predicted, which could help guide clinical decision making.