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Arlene V. Drack
Researcher at University of Iowa
Publications - 137
Citations - 6403
Arlene V. Drack is an academic researcher from University of Iowa. The author has contributed to research in topics: Visual acuity & Retinal degeneration. The author has an hindex of 36, co-authored 124 publications receiving 5281 citations. Previous affiliations of Arlene V. Drack include Georgetown University & University of Iowa Hospitals and Clinics.
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Journal ArticleDOI
Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial
Stephen R. Russell,Jean Bennett,Jennifer Wellman,Daniel C. Chung,Zi Fan Yu,Amy Tillman,Janet Wittes,Julie Pappas,Okan U. Elci,Sarah McCague,Dominique Cross,Kathleen A. Marshall,Jean Walshire,Taylor Kehoe,Hannah Reichert,Maria C. Davis,Leslie Raffini,Lindsey A. George,F. Parker Hudson,Laura E. Dingfield,Xiaosong Zhu,Julia A. Haller,Elliott H. Sohn,Vinit B. Mahajan,Wanda Pfeifer,Michelle T. Weckmann,Chris A. Johnson,Dina Y. Gewaily,Arlene V. Drack,Edwin M. Stone,Katie Wachtel,Francesca Simonelli,Bart P. Leroy,Bart P. Leroy,J. Fraser Wright,Katherine A. High,Albert M. Maguire +36 more
TL;DR: Voretigene neparvovec gene replacement improved functional vision in RPE65-mediated inherited retinal dystrophy previously medically untreatable.
Journal ArticleDOI
Genetic linkage of familial open angle glaucoma to chromosome 1q21–q31
Val C. Sheffield,Edwin M. Stone,Wallace L.M. Alward,Arlene V. Drack,A. Tim Johnson,Luan M. Streb,Brian E. Nichols +6 more
TL;DR: The atrial natriuretic peptide (ANP)/receptor system has been proposed to have a role in glaucoma and one of the ANP receptor genes maps to chromosome 1q.
Journal ArticleDOI
Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness.
N. Torben Bech-Hansen,Margaret J. Naylor,Tracy A. Maybaum,Rebecca Sparkes,Ben F. Koop,David G. Birch,Arthur A.B. Bergen,Clemens F. M. Prinsen,Robert C. Polomeno,Andreas Gal,Arlene V. Drack,Maria A. Musarella,Samuel G. Jacobson,Rockefeller S.L. Young,Richard G. Weleber +14 more
TL;DR: The role of other SLRP proteins suggests that mutant nyctalopin disrupts developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB.
Journal ArticleDOI
Butterfly-shaped pigment dystrophy of the fovea caused by a point mutation in codon 167 of the RDS gene.
Brian E. Nichols,Val C. Sheffield,Kimberlie Vandenburgh,Arlene V. Drack,Alan E. Kimura,Edwin M. Stone +5 more
TL;DR: A base substitution was identified in the peripherin (RDS) gene and DMA sequencing revealed a G to A transition in codon 167 that substitutes aspartic acid for a highly conserved glycine strongly suggesting that it causes the macular disease in this family of patients.
Journal ArticleDOI
Mutations in the RNA Granule Component TDRD7 Cause Cataract and Glaucoma
Salil A. Lachke,Fowzan S. Alkuraya,Stephen C. Kneeland,Takbum Ohn,Anton Aboukhalil,Anton Aboukhalil,Gareth R. Howell,Irfan Saadi,Resy Cavallesco,Yingzi Yue,Anne C.H. Tsai,K. Saidas Nair,Mihai Cosma,Mihai Cosma,Richard S. Smith,Emily Hodges,Suad AlFadhli,Amal Al-Hajeri,Hanan E. Shamseldin,Abdul Mutalib Behbehani,Gregory J. Hannon,Martha L. Bulyk,Martha L. Bulyk,Arlene V. Drack,Paul A. Anderson,Simon W. M. John,Simon W. M. John,Richard L. Maas +27 more
TL;DR: It is demonstrated that Tdrd7 nullizygosity in mouse causes cataracts, as well as glaucoma and an arrest in spermatogenesis, and a role for RGs in vertebrate organogenesis is demonstrated.