Elliott H. Sohn

TL;DR: Voretigene neparvovec gene replacement improved functional vision in RPE65-mediated inherited retinal dystrophy previously medically untreatable.

TL;DR: This longitudinal study in people with diabetes with no or minimal DR shows thatRDN precedes signs of microvasculopathy and that RDN is progressive and independent of glycated hemoglobin, age, and sex and represents a paradigm shift in the understanding of ocular diabetic complications.

TL;DR: Paracentral acute middle maculopathy may represent a novel variant of AMN that affects the middle layers of the macula above the OPL as diagnosed with SD-OCT imaging and it is proposed that each of these lesions may be explained by occlusion of either the superficial capillary plexus or deep capillaryplexus located in the innermost and outermost portion of the INL.

TL;DR: Aflibercept therapy appears to be beneficial in a subset of patients with neovascular age-related macular degeneration who exhibit recurrent or resistant intraretinal or subretinal fluid following multiple injections with either bevacizumab or ranibizumabs.

TL;DR: The significance of complement activation in AMD, particularly with respect to the formation of the membrane attack complex in the aging choriocapillaris, is discussed and a hypothesis for the pathogenesis of early AMD is presented.