Don Jefferys

TL;DR: It is postulate that hormones from both adrenal medulla and cortex are involved in the retention of information post-stress, and that these hormones act directly on the CNS rather than via the pituitary, since the response to adrenalectomy is not dependent on the presence of the pituitsary gland.

TL;DR: It is shown that retention of the immobile response in the Porsolt swim test is impaired in intact rats given the nitric oxide (NO) inhibitor L-N-arginine methyl ester (L-NAME), in a dose- and time-dependent manner, and it is concluded that the kappa-opioid and glucocorticoid mediated pathways previously shown to independently facilitate retention are mediated byNitric oxide.

TL;DR: In the Porsolt model swimming test, naive rats become progressively more immobile over a 15-min initial test (0-5 min, 30% immobile; 5-10 min, 50%, 10-15 min, -70%). Twenty-four hours later, rats have retained the response, being immobile for about 70% of a 5-min retest period.

TL;DR: Data are interpreted to show that one of the opioidergic pathways for the incorporation of information post-stress is kappa-selective, which suggests a possible physiological role for prodynorphin-derived peptides in memory.

TL;DR: In the Porsolt swimming test intact rats acquire and retain the immobile response indistinguishably at 25 and 30 degrees C; at both temperatures retention is abolished by administration of the glucocorticoid antagonist RU38486 and the kappa-selective opiate receptor antagonist MR2266 when given together, but not when either is given alone.