D
Donal J. Brennan
Researcher at Mater Misericordiae University Hospital
Publications - 150
Citations - 7861
Donal J. Brennan is an academic researcher from Mater Misericordiae University Hospital. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 42, co-authored 129 publications receiving 6598 citations. Previous affiliations of Donal J. Brennan include University College Dublin & Mater Health Services.
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Journal ArticleDOI
Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer
Donal J. Brennan,Jenny Brändstedt,Elton Rexhepaj,Michael E. Foley,Fredrik Pontén,Mathias Uhlén,William M. Gallagher,Darran P. O'Connor,Colm O'Herlihy,Karin Jirström,Karin Jirström +10 more
TL;DR: HMG-CoAR expression is an independent predictor of prolonged RFS in primary ovarian cancer and a surrogate marker of response to statin treatment, especially in conjunction with current chemotherapeutic regimens.
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Serum HE4 detects recurrent endometrial cancer in patients undergoing routine clinical surveillance
Donal J. Brennan,Andreas Hackethal,Kristy Mann,Irene Mutz-Dehbalaie,Heidi Fiegl,Christian Marth,Andreas Obermair +6 more
TL;DR: Serum HE4 measured during clinical follow-up may identify recurrent disease particularly in patients with endometrioid histology, and prospective validation of HE4 is warranted.
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Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray
Elin Möllerström,Anikó Kovács,Kristina Lövgren,Szilard Nemes,Ulla Delle,Anna Danielsson,Toshima Z. Parris,Donal J. Brennan,Karin Jirström,Per Karlsson,Khalil Helou +10 more
TL;DR: It is concluded that high-level BTG2 protein expression correlates with prolonged survival in patients with breast carcinoma.
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Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer.
Brittney S. Harrington,Yaowu He,Claire M. Davies,Claire M. Davies,S J Wallace,Mark N. Adams,Elizabeth A Beaven,Deborah K Roche,Catherine Kennedy,Naven Chetty,A.J. Crandon,Christopher Flatley,Niara Oliveira,Catherine Shannon,Anna deFazio,Anna V. Tinker,C. Blake Gilks,Brian Gabrielli,Donal J. Brennan,Jermaine Coward,Jermaine Coward,Jane E. Armes,Lewis Perrin,John D. Hooper +23 more
TL;DR: In vitro and mouse model data indicate that CDCP1 has a role in HGSC and that it can be targeted to inhibit progression of this cancer.
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Association of Implementing a Multidisciplinary Team Approach in the Management of Morbidly Adherent Placenta With Maternal Morbidity and Mortality.
Helena C. Bartels,Ailín C. Rogers,Donal O'Brien,Ruaidhri McVey,Jennifer Walsh,Donal J. Brennan +5 more
TL;DR: This meta-analysis highlights the improved maternal outcomes in patients with morbidly adherent placenta when managed by a multidisciplinary team in a specialist center when managing high-risk complex cases warrant expert management in centralized units.