D
Donald L. Durden
Researcher at University of California, San Diego
Publications - 122
Citations - 6165
Donald L. Durden is an academic researcher from University of California, San Diego. The author has contributed to research in topics: PTEN & Phosphorylation. The author has an hindex of 41, co-authored 117 publications receiving 5619 citations. Previous affiliations of Donald L. Durden include Children's Hospital Los Angeles & Fred Hutchinson Cancer Research Center.
Papers
More filters
Journal ArticleDOI
'Pseudopalisading' necrosis in glioblastoma: A familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis
TL;DR: Vaso-occlusive and prothrombotic mechanisms in GBM could readily explain the presence of pseudopalisading necrosis in tissue sections, the rapid peripheral expansion on neuroimaging, and the dramatic shift to an accelerated rate of clinical progression resulting from hypoxia-induced angiogenesis.
Journal ArticleDOI
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy.
TL;DR: The PTEN tumor suppressor protein is shown to protect p53 from survival signals, permitting p53 to function as a guardian of the genome as mentioned in this paper, and it can sensitize tumor cells to chemotherapy that relies on p53 activity.
Journal ArticleDOI
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
Joseph R. Garlich,Pradip De,Nandini Dey,Jing Dong Su,Xiaodong Peng,Antoinette Miller,Ravoori K. Murali,Yiling Lu,Gordon B. Mills,Vikas Kundra,H-K. Shu,Qiong Peng,Donald L. Durden +12 more
TL;DR: The development and antitumor activity of a novel RGDS-conjugated LY294002 prodrug, termed SF1126, which is designed to exhibit increased solubility and bind to specific integrins within the tumor compartment, resulting in enhanced delivery of the active compound to the tumor vasculature and tumor.
Journal ArticleDOI
PTEN controls tumor-induced angiogenesis
Shenghua Wen,Javor P. Stolarov,Michael P. Myers,Jing Dong Su,Michael Wigler,Nicholas K. Tonks,Donald L. Durden +6 more
TL;DR: Evidence is provided that PTEN regulates tumor-induced angiogenesis and the progression of gliomas to a malignant phenotype via the regulation of phosphoinositide-dependent signals.
Journal ArticleDOI
PTEN and Hypoxia Regulate Tissue Factor Expression and Plasma Coagulation by Glioblastoma
TL;DR: Results show that PTEN loss and hypoxia up-regulate TF expression and promote plasma clotting by glioma cells, suggesting that these mechanisms may underlie intravascular thrombosis and pseudopalisading necrosis in glioblastoma.