Donald L. Fine

TL;DR: Since the microculture tetrazolium assay provides sensitive and reproducible indices of growth as well as drug sensitivity in individual cell lines over the course of multiple passages and several months' cultivation, it appears suitable for initial-stage in vitro drug screening.

TL;DR: The intrapulmonary model was used successfully for establishment and propagation of xenografts derived directly from enzymatically digested, fresh human lung tumor specimens obtained at the time of diagnostic thoracotomy and representing all four major lung cancer cell types as well as a bronchioloalveolar cell carcinoma.

TL;DR: These data demonstrate that both the i.b. and i.t. models should be useful for the in vivo propagation and study of certain human pulmonary and nonpulmonary carcinomas as well as being advantageous for future studies of cancer biology and developmental therapeutics.

TL;DR: It is concluded that this model of squamous cell bronchogenic carcinoma should prove useful in the study of tumor ultrastructure, the immunologic response to cancer, and the relationship of diet to cancer.

TL;DR: Several metastatic models that are based on and complement a panel of cell strains used in large-scale in vitro drug screening are developed, which may provide practical models for experimental drug and immunotherapeutic trials.