A
Anne Monks
Researcher at Leidos
Publications - 101
Citations - 28470
Anne Monks is an academic researcher from Leidos. The author has contributed to research in topics: Cell culture & Cancer. The author has an hindex of 45, co-authored 101 publications receiving 27179 citations. Previous affiliations of Anne Monks include National Institutes of Health & Science Applications International Corporation.
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Journal ArticleDOI
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Philip Skehan,Ritsa Storeng,Dominic A. Scudiero,Anne Monks,James B. McMahon,David T. Vistica,Jonathan T. Warren,Heidi R. Bokesch,Susan Kenney,Michael R. Boyd +9 more
TL;DR: The SRB assay provides a sensitive measure of drug-induced cytotoxicity, is useful in quantitating clonogenicity, and is well suited to high-volume, automated drug screening.
Journal Article
Feasibility of Drug Screening with Panels of Human Tumor Cell Lines Using a Microculture Tetrazolium Assay
Michael C. Alley,Dominic A. Scudiero,Anne Monks,Miriam L. Hursey,Maciej Czerwinski,Donald L. Fine,B. J. Abbott,Joseph G. Mayo,Robert H. Shoemaker,Michael R. Boyd +9 more
TL;DR: Since the microculture tetrazolium assay provides sensitive and reproducible indices of growth as well as drug sensitivity in individual cell lines over the course of multiple passages and several months' cultivation, it appears suitable for initial-stage in vitro drug screening.
Journal ArticleDOI
Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines
Anne Monks,Dominic A. Scudiero,Philip Skehan,Robert H. Shoemaker,Kenneth D. Paull,David T. Vistica,Curtis Hose,John Langley,Paul Cronise,Anne Vaigro-Wolff,Marcia Gray-Goodrich,H. D. Campbell,Joseph G. Mayo,Michael R. Boyd +13 more
TL;DR: A pilot-scale, in vitro, anticancer drug screen utilizing a panel of 60 human tumor cell lines organized into subpanels representing leukemia, melanoma, and cancers of the lung, colon, kidney, ovary, and central nervous system is described.
Journal Article
Evaluation of a Soluble Tetrazolium/Formazan Assay for Cell Growth and Drug Sensitivity in Culture Using Human and Other Tumor Cell Lines
Dominic A. Scudiero,Robert H. Shoemaker,Kenneth D. Paull,Anne Monks,Siobhan Tierney,Thomas H. Nofziger,Michael J. Currens,Donna Seniff,Michael R. Boyd +8 more
TL;DR: The new XTT reagent provides for a simplified, in vitro cell growth assay with possible applicability to a variety of problems in cellular pharmacology and biology, but still shares many of the limitations and potential pitfalls of MTT or other tetrazolium-based assays.
Journal ArticleDOI
An Information-Intensive Approach to the Molecular Pharmacology of Cancer
John N. Weinstein,Timothy G. Myers,Patrick M. O'Connor,Stephen H. Friend,Albert J. Fornace,Kurt W. Kohn,Tito Fojo,Susan E. Bates,Larry Rubinstein,N. Leigh Anderson,John K. Buolamwini,William W. van Osdol,Anne Monks,Dominic A. Scudiero,Edward A. Sausville,Daniel W. Zaharevitz,Barry Bunow,Vellarkad N. Viswanadhan,George S. Johnson,Robert Wittes,Kenneth D. Paull +20 more
TL;DR: Information is being used to search for candidate anticancer drugs that are not dependent on intact p53 suppressor gene function for their activity, and it remains to be seen how effective this information-intensive strategy will be at generating new clinically active agents.