D
Donald Y.M. Leung
Researcher at University of Colorado Denver
Publications - 16
Citations - 5624
Donald Y.M. Leung is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Atopic dermatitis & Filaggrin. The author has an hindex of 9, co-authored 16 publications receiving 5311 citations. Previous affiliations of Donald Y.M. Leung include National Jewish Health & Anschutz Medical Campus.
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Journal ArticleDOI
Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges.
Mao-Qiang Man,Yutaka Hatano,Seung Hun Lee,M. Man,Sandra Chang,Kenneth R. Feingold,Donald Y.M. Leung,Walter M. Holleran,Yoshikazu Uchida,Peter M. Elias +9 more
TL;DR: Here, multiple Ox challenges to normal murine skin produce a chronic Th2-like HR, with multiple features of human AD, which could prove useful for evaluating both pathogenic mechanisms and potential therapies for AD.
Journal ArticleDOI
The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype
Donald Y.M. Leung,Agustin Calatroni,Livia S. Zaramela,Petra LeBeau,Nathan Dyjack,Kanwaljit K. Brar,Gloria David,Keli Johnson,Susan Leung,Marco A. Ramirez-Gama,Bo Liang,Cydney Rios,M.T. Montgomery,Brittany N. Richers,Clifton F. Hall,Kathryn A. Norquest,John Jung,Irina Bronova,Simion Kreimer,C. Conover Talbot,Debra Crumrine,Robert N. Cole,Peter M. Elias,Karsten Zengler,Max A. Seibold,Evgeny Berdyshev,Elena Goleva +26 more
TL;DR: The findings of this study suggest that the most superficial compartment of nonlesional skin in AD FA+ has unique properties associated with an immature skin barrier and type 2 immune activation.
Journal ArticleDOI
Epithelial barrier repair and prevention of allergy
TL;DR: Current epithelial barrier repair strategies are examined as an approach for allergy prevention or intervention and the link between altered skin barrier formation and the pathogenesis of AD is analyzed.
Journal ArticleDOI
Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?
Helen A. Brough,Helen A. Brough,Helen A. Brough,Kari C. Nadeau,Sayantani B. Sindher,Shifaa S. Alkotob,Susan Chan,Susan Chan,Susan Chan,Henry T. Bahnson,Donald Y.M. Leung,Gideon Lack,Gideon Lack,Gideon Lack +13 more
TL;DR: An overview of the atopic march and immune mechanism underlying the sensitization and effector phase of food allergy is provided and experimental models and human data that support the concept of epicutaneous sensitization are presented, forming one half of the dual‐allergen exposure hypothesis.