D
Donatella Aldinucci
Researcher at University of Florence
Publications - 98
Citations - 5895
Donatella Aldinucci is an academic researcher from University of Florence. The author has contributed to research in topics: Cytokine & Tumor microenvironment. The author has an hindex of 39, co-authored 96 publications receiving 5270 citations. Previous affiliations of Donatella Aldinucci include University of Trieste & University of Padua.
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A sensitive spectrophotometric method for the determination of superoxide dismutase activity in tissue extracts.
TL;DR: Experiments on rat liver cytosol have shown the specificity of the spectrophotometric method for superoxide dismutase, and common cellular components do not interfere with the measurement, except for hemoglobin when present at relatively high concentrations.
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The inflammatory chemokine CCL5 and cancer progression.
TL;DR: This review summarizes updated information on the role of CCL5 and its receptor CCR5 in cancer cell proliferation, metastasis, and the formation of an immunosuppressive microenvironment and highlights the development of newer therapeutic strategies.
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The role of the EGFR signaling in tumor microenvironment
Antonella De Luca,Adele Carotenuto,Annamaria Rachiglio,Marianna Gallo,Monica R. Maiello,Donatella Aldinucci,Antonio Pinto,Nicola Normanno +7 more
TL;DR: Findings suggest that the EGFR system is an important mediator, within the tumor microenvironment, of autocrine and paracrine circuits that result in enhanced tumor growth.
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The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape
TL;DR: This review summarizes updated information on the complex interactions between the HRS cells and their tissue microenvironment and highlights the development of newer therapeutic strategies aimed at targeting the non‐malignant inflammatory/immune cellular components of HL that are involved in cancer cell growth and/or immune escape.
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Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines.
Alessia Carbone,Annunziata Gloghini,Valter Gattei,Donatella Aldinucci,Massimo Degan,P. De Paoli,Vittorina Zagonel,Antonio Pinto +7 more
TL;DR: The data indicate that CD40 is a useful antigen for immunodetection and identification of tumor cells in all subtypes of HD, and suggest that it may play a role in the regulation of RS cell expansion and the contact-dependent interactions of these cells with cytokine-producing T lymphocytes.