D
Dong-Ki Kim
Researcher at Texas A&M University
Publications - 12
Citations - 1038
Dong-Ki Kim is an academic researcher from Texas A&M University. The author has contributed to research in topics: Mesenchymal stem cell & Stromal cell. The author has an hindex of 7, co-authored 12 publications receiving 715 citations. Previous affiliations of Dong-Ki Kim include Texas A&M Health Science Center & Texas A&M Health Science Center College of Medicine.
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Journal ArticleDOI
Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI
TL;DR: The results presented here address several limitations to progress in the field by developing protocols to produce and isolate large numbers of extracellular vesicles from stem-like cells found in the bone marrow, and developing an in vivo assay for efficacy of the cells in suppressing neuroinflammation after traumatic brain injury (TBI) in mice.
Journal ArticleDOI
Intranasal MSC-derived A1-exosomes Ease Inflammation, and Prevent Abnormal Neurogenesis and Memory Dysfunction After Status Epilepticus
Qianfa Long,Dinesh Upadhya,Bharathi Hattiangady,Dong-Ki Kim,Su Yeon An,Bing Shuai,Darwin J. Prockop,Ashok K. Shetty +7 more
TL;DR: Investigation of the effects of intranasal administration of extracellular vesicles secreted from human bone marrow-derived mesenchymal stem cells on SE-induced adverse changes demonstrated that A1-exosome treatment after SE led to reduced neuron loss and inflammation, maintenance of normal neurogenesis, and preservation of cognitive and memory function.
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MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis
Taeko Shigemoto-Kuroda,Joo Youn Oh,Dong-Ki Kim,Hyun Jeong Jeong,Se Yeon Park,Hyun Ju Lee,Jong Woo Park,Tae Wan Kim,Su Yeon An,Darwin J. Prockop,Ryang Hwa Lee +10 more
TL;DR: The data demonstrate that MSC-derived EVs effectively prevent the onset of disease in both type 1 diabetes and experimental autoimmune uveoretinitis, raising the possibility that M SCs may be an alternative to cell therapy for autoimmune disease prevention.
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Administration of TSG-6 improves memory after traumatic brain injury in mice.
Jun Watanabe,Ashok K. Shetty,Bharathi Hattiangady,Dong-Ki Kim,Jessica E. Foraker,Hidetaka Nishida,Darwin J. Prockop +6 more
TL;DR: The data suggested that acute administration of TSG-6 may be an effective therapy for decreasing some of the long-term consequences of TBI.
Journal ArticleDOI
Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain
Maheedhar Kodali,Olagide W. Castro,Dong-Ki Kim,Alicia Thomas,Bing Shuai,Sahithi Attaluri,Raghavendra Upadhya,Daniel Leite Góes Gitaí,Leelavathi N. Madhu,Darwin J. Prockop,Ashok K. Shetty +10 more
TL;DR: Unilateral IN administration of EVs is efficient for delivering EVs bilaterally into neurons and microglia in multiple regions in the intact or injured forebrain, implying that injury-related signals likely play a role in targeting of EVs into neurons, which may be beneficial for EV therapy in various neurodegenerative conditions.