Institution
Texas A&M Health Science Center College of Medicine
About: Texas A&M Health Science Center College of Medicine is a based out in . It is known for research contribution in the topics: Population & Mesenchymal stem cell. The organization has 1538 authors who have published 1192 publications receiving 39226 citations.
Papers published on a yearly basis
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Cornell University1, Boston University2, Johns Hopkins University3, University of Miami4, University of California, San Francisco5, Texas A&M Health Science Center College of Medicine6, Centers for Disease Control and Prevention7, University of Washington8, Case Western Reserve University9, University of Pennsylvania10, Denver Health Medical Center11, University of Michigan12, University of California, Davis13, University of California, Los Angeles14, United States Department of Veterans Affairs15, Washington University in St. Louis16, Wake Forest University17, University of Utah18, Memorial Sloan Kettering Cancer Center19
TL;DR: These recommendations address the best approaches for antibiotic stewardship programs to influence the optimal use of antibiotics.
Abstract: Evidence-based guidelines for implementation and measurement of antibiotic stewardship interventions in inpatient populations including long-term care were prepared by a multidisciplinary expert panel of the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. The panel included clinicians and investigators representing internal medicine, emergency medicine, microbiology, critical care, surgery, epidemiology, pharmacy, and adult and pediatric infectious diseases specialties. These recommendations address the best approaches for antibiotic stewardship programs to influence the optimal use of antibiotics.
1,969 citations
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TL;DR: Quantitative assays for human DNA and mRNA were used to examine the paradox that intravenously infused human multipotent stromal cells (hMSCs) can enhance tissue repair without significant engraftment and suggest that improvements in animal models and patients after i.v. infusions of MSCs are at least in part explained by activation of M SCs to secrete TSG-6.
1,626 citations
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Harvard University1, Brigham and Women's Hospital2, Centers for Disease Control and Prevention3, Emory University4, University of Pittsburgh5, University of Michigan6, National Institutes of Health7, Hospital Corporation of America8, Texas A&M Health Science Center College of Medicine9, Washington University in St. Louis10
TL;DR: In clinical data from 409 hospitals, sepsis was present in 6% of adult hospitalizations, and in contrast to claims-based analyses, neither the incidence of sepsi nor the combined outcome of death or discharge to hospice changed significantly between 2009-2014.
Abstract: Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time. Objective To estimate the US national incidence of sepsis and trends using detailed clinical data from the electronic health record (EHR) systems of diverse hospitals. Design, Setting, and Population Retrospective cohort study of adult patients admitted to 409 academic, community, and federal hospitals from 2009-2014. Exposures Sepsis was identified using clinical indicators of presumed infection and concurrent acute organ dysfunction, adapting Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) criteria for objective and consistent EHR-based surveillance. Main Outcomes and Measures Sepsis incidence, outcomes, and trends from 2009-2014 were calculated using regression models and compared with claims-based estimates using International Classification of Diseases, Ninth Revision, Clinical Modification codes for severe sepsis or septic shock. Case-finding criteria were validated against Sepsis-3 criteria using medical record reviews. Results A total of 173 690 sepsis cases (mean age, 66.5 [SD, 15.5] y; 77 660 [42.4%] women) were identified using clinical criteria among 2 901 019 adults admitted to study hospitals in 2014 (6.0% incidence). Of these, 26 061 (15.0%) died in the hospital and 10 731 (6.2%) were discharged to hospice. From 2009-2014, sepsis incidence using clinical criteria was stable (+0.6% relative change/y [95% CI, −2.3% to 3.5%], P = .67) whereas incidence per claims increased (+10.3%/y [95% CI, 7.2% to 13.3%], P P = .004), but there was no significant change in the combined outcome of death or discharge to hospice (−1.3%/y [95% CI, −3.2% to 0.6%], P = .19). In contrast, mortality using claims declined significantly (−7.0%/y [95% CI, −8.8% to −5.2%], P P P P = .23). Conclusions and Relevance In clinical data from 409 hospitals, sepsis was present in 6% of adult hospitalizations, and in contrast to claims-based analyses, neither the incidence of sepsis nor the combined outcome of death or discharge to hospice changed significantly between 2009-2014. The findings also suggest that EHR-based clinical data provide more objective estimates than claims-based data for sepsis surveillance.
1,105 citations
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Chinese Academy of Sciences1, Texas A&M University2, East China Normal University3, Peking University4, Florida International University5, Shandong University6, Beijing Normal University7, Xi'an Jiaotong University8, Texas Tech University9, Lanzhou University10, Texas A&M Health Science Center College of Medicine11, Hospital Corporation of America12, Texas College13, California Institute of Technology14, Ocean University of China15, Wuhan University16, Guangdong University of Technology17, Hebrew University of Jerusalem18, University of East Anglia19, University of California, San Diego20
TL;DR: The results explain the outstanding sulfur problem during the historic London Fog formation and elucidate the chemical mechanism of severe haze in China, and suggest that effective haze mitigation is achievable by intervening in the sulfate formation process with NH3 and NO2 emission control measures.
Abstract: Sulfate aerosols exert profound impacts on human and ecosystem health, weather, and climate, but their formation mechanism remains uncertain. Atmospheric models consistently underpredict sulfate levels under diverse environmental conditions. From atmospheric measurements in two Chinese megacities and complementary laboratory experiments, we show that the aqueous oxidation of SO2 by NO2 is key to efficient sulfate formation but is only feasible under two atmospheric conditions: on fine aerosols with high relative humidity and NH3 neutralization or under cloud conditions. Under polluted environments, this SO2 oxidation process leads to large sulfate production rates and promotes formation of nitrate and organic matter on aqueous particles, exacerbating severe haze development. Effective haze mitigation is achievable by intervening in the sulfate formation process with enforced NH3 and NO2 control measures. In addition to explaining the polluted episodes currently occurring in China and during the 1952 London Fog, this sulfate production mechanism is widespread, and our results suggest a way to tackle this growing problem in China and much of the developing world.
1,027 citations
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TL;DR: Insight is provided into the various properties of cardiac fibroblasts that helps illustrate their importance in maintaining proper cardiac function, as well as their critical role in the remodeling heart.
Abstract: The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes, endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated that there are undulating changes in cardiac cell populations during embryonic development, through neonatal development and into the adult. Transient cell populations include lymphocytes, mast cells, and macrophages, which can interact with these permanent cell types to affect cardiac function. It has also been observed that there are marked differences in the makeup of the cardiac cell populations depending on the species, which may be important when examining myocardial remodeling. Current dogma states that the fibroblast makes up the largest cell population of the heart; however, this appears to vary for different species, especially mice. Cardiac fibroblasts play a critical role in maintaining normal cardiac function, as well as in cardiac remodeling during pathological conditions such as myocardial infarct and hypertension. These cells have numerous functions, including synthesis and deposition of extracellular matrix, cell-cell communication with myocytes, cell-cell signaling with other fibroblasts, as well as with endothelial cells. These contacts affect the electrophysiological properties, secretion of growth factors and cytokines, as well as potentiating blood vessel formation. Although a plethora of information is known about several of these processes, relatively little is understood about fibroblasts and their role in angiogenesis during development or cardiac remodeling. In this review, we provide insight into the various properties of cardiac fibroblasts that helps illustrate their importance in maintaining proper cardiac function, as well as their critical role in the remodeling heart.
894 citations
Authors
Showing all 1538 results
Name | H-index | Papers | Citations |
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Darwin J. Prockop | 128 | 576 | 87066 |
Guoyao Wu | 122 | 764 | 56270 |
Michael A. Hitt | 120 | 361 | 74448 |
Stephen Safe | 116 | 784 | 60588 |
Fuller W. Bazer | 109 | 803 | 46194 |
Casey Papovich | 105 | 448 | 47424 |
Thomas E. Spencer | 98 | 383 | 32248 |
Peter A. McCullough | 92 | 662 | 36541 |
Lawrence A. Lavery | 81 | 338 | 24677 |
William J. Murphy | 80 | 293 | 25360 |
R. Duane Ireland | 79 | 192 | 38949 |
James C. Sacchettini | 77 | 390 | 32514 |
Gianfranco Alpini | 74 | 384 | 16288 |
Robert C. Burghardt | 73 | 315 | 17698 |
Peter F. Davies | 70 | 206 | 20035 |