D
Dong Lin
Researcher at University of California, San Francisco
Publications - 18
Citations - 2519
Dong Lin is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Pregnenolone & Cholesterol side-chain cleavage enzyme. The author has an hindex of 13, co-authored 17 publications receiving 2462 citations. Previous affiliations of Dong Lin include Albert Einstein College of Medicine & University of California.
Papers
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Journal ArticleDOI
cAMP post-transcriptionally diminishes the abundance of adrenodoxin reductase mRNA.
TL;DR: Adrenodoxin reductase (AR; ferridoxin: NADP+ oxidoreductase, EC 1.18.2) is a flavoprotein that mediates electron transport from NADPH to all known mitochondrial forms of cytochrome P450 as mentioned in this paper.
Journal ArticleDOI
Regulation of proteins in the cholesterol side-chain cleavage system in JEG-3 and Y-1 cells.
Stephen M. Black,Grazyna D. Szklarz,Jennifer Ann Harikrishna,Dong Lin,C. R. Wolf,Walter L. Miller +5 more
TL;DR: These studies show that the three proteins of the cholesterol side-chain cleavage system behave in response to 8Br-cAMP and PMA/A23187 as predicted from the study of their genes and mRNAs, indicating that the chronic regulation of steroidogenesis in these cell systems is regulated principally at the level of mRNA abundance.
Journal ArticleDOI
Cloning and sequence of the human adrenodoxin reductase gene.
TL;DR: RNase protection experiments show that transcription is initiated from multiple sites in the 5' flanking region, located about 21-91 base pairs upstream from the AUG translational initiation codon.
Journal ArticleDOI
Congenital lipoid adrenal hyperplasia : genes for P450scc, side chain cleavage enzyme, are normal
Paul Saenger,Paul Saenger,Dong Lin,Dong Lin,Stephen E. Gitelman,Stephen E. Gitelman,Walter L. Miller,Walter L. Miller +7 more
TL;DR: The results suggest that the lesion in lipoid CAH is not in the P 450scc system or in any known step upstream from P450scc.
Patent
Identification of gene mutations associated with congenital lipoid adrenal hyperplasia
TL;DR: An isolated DNA or RNA molecule can be an RNA molecule in which U replaces T in any of said sequences with the provisos that (1) the second sequence is at least 95 % identical to the first or second sequence, (2) the third or fourth sequence is not present in mouse StAR cDNA, and (3) the fifth or sixth sequence contains no more than 20 inserted nucleotides as discussed by the authors.