Showing papers in "The Journal of Steroid Biochemistry and Molecular Biology in 1993"

TL;DR: It is suggested that the high concentration of lignans in vegetarians, by inhibiting aromatase in peripheral and/or cancer cells and lowering estrogen levels, may play a protective role as antipromotional compounds during growth of estrogen-dependent cancers.

TL;DR: Results indicate that estradiol and the isoflavonoids exert their effects on AlkP by similar interactions with the estrogen receptor, with potencies depending on binding affinities.

TL;DR: It is concluded that estrogens especially estriol and 17 beta-estradiol are naturally occurring antioxidants.

TL;DR: An in vitro technique based on rainbow trout hepatocytes incubated in a basic medium free of any additional growth factors or estrogenic chemicals and uses the production of vitellogenin as a marker for the estrogenic potency of the compounds tested can provide complementary results about the activity of chemicals which need an hepatic metabolization to be estrogenic.

TL;DR: The use of GC/MS and microbore HPLC/electrospray mass spectrometry for clinical studies in hypertension and mineralocorticoid research is described and this method is able to distinguish almost all steroid related disorders.

TL;DR: Results indicate that AR gene mutations occur in relation to endocrine therapy-resistance, although the mutation was found in 1 out of 8 resistant cases (12.5%) at autopsy.

TL;DR: It is proposed that the C-C bond cleavage reaction occurs through the participation of the FeIII-O-OH species that is trapped by the electrophilic property of the carbonyl compound giving a peroxide adduct that fragments to produce an acyl-carbon cleavage.

TL;DR: Within several nuclei, sex differences in aromatase induction correlated with differences in nuclear androgen receptor concentrations suggesting that neural responsiveness to testosterone is sexually differentiated.

TL;DR: The activational effects of testosterone (T) on male copulatory behavior are mediated by its aromatization into estradiol and the activating effects of T seem to result from a synergistic action of androgenic and estrogenic metabolites of the steroid.

TL;DR: Chrysin, the most potent of the naturally-occurring flavonoids, was similar in potency and effectiveness to AG, a pharmaceutical aromatase inhibitor used clinically in cases of estrogen-dependent carcinoma.

TL;DR: It can be concluded that steroid analysis in the amniotic fluid is an accurate method but provides only a late (second trimester) diagnosis, while an early and accurate diagnosis now relies on adequate molecular genetic studies on chorion villus biopsies.

TL;DR: The finding suggests that the mechanism by which gonadotropins promote decidualization of human endometrial stromal cells in vitro involves the introduction of cAMP, a compound that the authors have found to elicit the expression of PRL in this system.

TL;DR: The results indicate the existence of two distinct estrogen-producing neuron systems in the rat brain: a "limbic ring" of aromatase-labeled neurons of the lateral septum-bed nucleus-amygdala complex unresponsive to gonadectomy; and a sex hormone-sensitive "hypothalamic" aromat enzyme neuron system.

TL;DR: The expression of P450arom in human ovary appears to utilize a promoter proximal to the translation start site, which is not utilized in placenta; instead, the promoter used to drive aromatase expression in placas is > or = 40 kb upstream from the translational start site.

TL;DR: It is concluded that this chimeric response faithfully reflects estrogenic action in the cell and can be used to develop different aspects of the endocrine research.

TL;DR: The phenomenon of autoinduction of nuclear receptors of the steroid/thyroid hormone gene family is discussed, and its significance in the context of the developmental and gene regulatory function of the ligands is illustrated.

TL;DR: It is concluded that IL-6 may have an important role in regulating aromatase activity in breast tissues.

TL;DR: The ability of EB 1089 to affect calcium metabolism in vivo in rats is decreased, compared to 1,25(OH)2D3, which makes it an interesting candidate for treatment of cancer.

TL;DR: Local conversion of Org OD 14 to the 4-ene isomer, a metabolite with higher progestagenic and lower estrogenic potencies than those of its precursor, selectively prevents undesirable proliferative stimulation of the endometrium in postmenopausal users while preserving its beneficial effects on other tissues, including bone.

TL;DR: All three xPPARs appear to be activated by synthetic peroxisome proliferators as well as by naturally occurring fatty acids, suggesting that a common mode of action exists for all the members of this subfamily of nuclear hormone receptors.

TL;DR: Analysis of described mutations indicates that they are spread throughout the gene, either associated with partial or complete androgen insensitivity, and will certainly yield important new insights into the molecular basis of androgen action.

TL;DR: Placental aromatase is responsible for the highly elevated levels of the catechol estrogen and 19-hydroxyandrogen during pregnancy and the active site structure holds the steroid substrates to face their beta-side of the A-ring to the heme, tilted in such a way as to make the 2-position of estrogens and 19-, 1-, and 2-positions of androgens available for monooxygenation.

TL;DR: Results show that contacts involving both the DNA and steroid binding domains are involved in dimerization and high affinity DNA binding, and that amino acids within the recognition helix of the DNA-binding domain in discriminating between cognate DNA response elements for the glucocorticoid receptor and closely related binding sites for other nuclear receptors.

TL;DR: The ratio (T/ET)G, which is the sole official criterium for assessment of T self-administration by athletes, increased above the threshold value of 6 in most of the subjects, but not all, after the two highest dosage T regimens, and returned to normal during the recovery period.

TL;DR: It is suggested that the observed protease-resistant conformation may introduce a different configuration to the receptor and therefore may affect the receptor in various ways, but most likely is involved in converting the receptor from a negative regulator to a positive activator.

TL;DR: The compartmentalization of two strictly correlated enzymes (5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase) in separate central nervous system (CNS) cell populations suggests the simultaneous participation of neurons and glial cells in the 5 alpha- reductive metabolism of testosterone.

TL;DR: It is proposed that interactions between FSH, E2 and TGF-beta lead to the exponential increase in serum E2 levels that occurs during the follicular phase of the cycle and that the growth-promoting actions of FSH on Sertoli cells may depend upon a cascade series of events involving estrogens and T GF-beta.

TL;DR: It is concluded that CGS 20267 is a potent, specific inhibitor of estrogen biosynthesis in postmenopausal patients with metastatic breast cancer and effectively reduces blood and urine estrogens to undetectable levels.

TL;DR: Findings that low doses of CX given i.c.v. can alter the activity of 11-HSD in specific brain regions without affecting its activity in peripheral tissues, and only marginally in the pituitary, provides a method to study the central role of this enzyme independently of systemic effects.

TL;DR: An analysis of the Free Androgen Index's derivation from the Law of Mass Action reveals an implied assumption that the binding capacity of sex hormone binding globulin should greatly exceed the concentration of its ligand testosterone that does not hold in adult males for whom the use of FAI is therefore inappropriate.