Dong Seok Kim

TL;DR: The physiological role of the GLP-1R pathway in the gut–brain axis and the therapeutic strategy of GLP -1R stimulation for the treatment of neurodegenerative diseases focused on PD are reviewed.

TL;DR: The data suggest that post-treatment with PT302 provides long-lasting Exendin-4 release and reduces neurodegeneration of nigrostriatal dopaminergic neurons in a 6-hydroxydopamine rat model of PD at a clinically relevant dose.

TL;DR: Treatment with exendin-4 (Ex-4) delivered by subcutaneous micro-osmotic pumps prevented the induction of both cognitive deficits and B-TBI induced changes in SYP staining, implying that treatment with Ex-4 may represent a viable option for the management of secondary events triggered by blast-induced, mild traumatic brain injury.

TL;DR: A review of peptide vaccine development can be found in this article focusing on the role of peptides in the vaccine formulation from epitope to adjuvant, and the future perspectives of vaccine and immunotherapy.

TL;DR: A quantitative method of biolistics to analyze gene expression in organotypic cultures of hippocampus and hypothalamus using co-transfection of the experimental promoters and standard promoters coupled to different reporters, with the standard promoter-reporter construct used to 'normalize' the experimental data.