Dongni Yan

TL;DR: The importance of arecoline is supported by its being the world's fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine) and social and historical aspects of its use and abuse.

TL;DR: This study supports evolutionarily conserved behavioral and physiological effects of kava and kavalactones in zebrafish, implicates brain monoamines in their acute effects, and provides novel important insights into potential role of neuroglial and epigenetic mechanisms in long-term kava use.

TL;DR: It is suggested that the present model successfully recapitulates lasting behavioral and endocrine symptoms of clinical stress-related disorders, also implicating long-term changes in neuroglia, neuroinflammation, apoptosis and epigenetic modulation in their pathogenesis.

TL;DR: How DM alters brain functions and behavior in zebrafish is discussed, and their translational relevance to studying DM-related CNS pathogenesis in humans is summarized.

TL;DR: Clinical and experimental data on kava psychopharmacology are discussed, chemistry and synthesis of kavalactones are summarized and its societal impact, drug use and abuse potential, and future perspectives on translational kava research are reviewed.