Institution
Loma Linda University Medical Center
Healthcare•Loma Linda, California, United States•
About: Loma Linda University Medical Center is a healthcare organization based out in Loma Linda, California, United States. It is known for research contribution in the topics: Transplantation & Population. The organization has 2998 authors who have published 3282 publications receiving 85169 citations. The organization is also known as: Loma Linda Medical Center.
Topics: Transplantation, Population, Radiation therapy, Proton therapy, Medicine
Papers published on a yearly basis
Papers
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TL;DR: Intended for use by physicians, these recommendations suggest preferred approaches to the diagnostic, therapeutic, and preventive aspects of care intended to be flexible, in contrast to standards of care, which are inflexible policies to be followed in every case.
876 citations
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University of Birmingham1, University College London2, University of Modena and Reggio Emilia3, Taipei Veterans General Hospital4, Loma Linda University Medical Center5, The Heart Research Institute6, Brigham and Women's Hospital7, Stanford University8, UCL Institute of Neurology9, Uniformed Services University of the Health Sciences10
TL;DR: Oral anticoagulation is the optimal choice of antithrombotic therapy for patients with AF with ≥1 non‐sex CHA2DS2‐VASc stroke risk factor(s), and stroke prevention (ie, oral antICOagulation therapy) is the next step.
695 citations
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TL;DR: Oxytocin and altruism together predicted almost half the interpersonal variation in generosity, indicating that generosity is associated with both altruism as well as an emotional identification with another person.
Abstract: Human beings routinely help strangers at costs to themselves. Sometimes the help offered is generous—offering more than the other expects. The proximate mechanisms supporting generosity are not well-understood, but several lines of research suggest a role for empathy. In this study, participants were infused with 40 IU oxytocin (OT) or placebo and engaged in a blinded, one-shot decision on how to split a sum of money with a stranger that could be rejected. Those on OT were 80% more generous than those given a placebo. OT had no effect on a unilateral monetary transfer task dissociating generosity from altruism. OT and altruism together predicted almost half the interpersonal variation in generosity. Notably, OT had twofold larger impact on generosity compared to altruism. This indicates that generosity is associated with both altruism as well as an emotional identification with another person.
629 citations
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TL;DR: Development of NSF was strongly associated with gadodiamide administration in the setting of either acute hepatorenal syndrome or dialysis-dependent chronic renal insufficiency.
Abstract: OBJECTIVE. Nephrogenic systemic fibrosis (NSF) is a rare multisystemic fibrosing disorder that principally affects the skin but may affect other organs of patients with renal insufficiency. The purpose of our study was to identify any common risk factors and determine whether IV gadodiamide is associated with the development of NSF.MATERIALS AND METHODS. A retrospective chart review was performed for all 12 patients diagnosed with NSF at our institution between 2000 and 2006 to identify the clinical manifestations, timing, and dose of gadodiamide administration; dialysis records; concurrent medications; comorbid conditions and surgeries; laboratory findings; imaging findings; and clinical outcome. A review of the dialysis and MR records between 2000 and 2006 showed 559 MRI examinations on 168 dialysis patients (including 301 contrast-enhanced examinations).RESULTS. NSF was diagnosed by clinical findings and tissue diagnosis. All 12 patients had renal insufficiency—eight with dialysis-dependent chronic ren...
584 citations
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TL;DR: High-dose proton RT offers excellent chances of lasting tumor control and survival, with acceptable risks, and all small- and medium-sized tumors with no demonstrable brainstem involvement have been controlled.
Abstract: Object Local tumor control, patient survival, and treatment failure outcomes were analyzed to assess treatment efficacy in 58 patients in whom fractionated proton radiation therapy (RT) was administered for skull base chordomas and chondrosarcomas. Methods Between March 1992 and January 1998, a total of 58 patients who could be evaluated were treated for skull base tumors, 33 for chordoma and 25 for chondrosarcoma. Following various surgical procedures, residual tumor was detected in 91% of patients; 59% demonstrated brainstem involvement. Target dosages ranged from 64.8 and 79.2 (mean 70.7) Co Gy equivalent. The range of follow up was 7 to 75 months (mean 33 months). In 10 patients (17%) the treatment failed locally, resulting in local control rates of 92% (23 of 25 patients) for chondrosarcomas and 76% (25 of 33 patients) for chordomas. Tumor volume and brainstem involvement influenced control rates. All tumors with volumes of 25 ml or less remained locally controlled, compared with 56% of tumors larger than 25 ml (p = 0.02); 94% of patients without brainstem involvement did not experience recurrence; in patients with brainstem involvement (and dose reduction because of brainstem tolerance constraints) the authors achieved a tumor control rate of 53% (p = 0.04). Three patients died of their disease, and one died of intercurrent disease. Actuarial 5-year survival rates were 100% for patients with chondrosarcoma and 79% for patients with chordoma. Grade 3 and 4 late toxicities were observed in four patients (7%) and were symptomatic in three (5%). Conclusions High-dose proton RT offers excellent chances of lasting tumor control and survival, with acceptable risks. In this series all small- and medium-sized tumors with no demonstrable brainstem involvement have been controlled; all such patients are alive. Surgical debulking enhanced delivery of full tumoricidal doses, but even patients with large tumors and disease abutting crucial normal structures benefited.
491 citations
Authors
Showing all 3009 results
Name | H-index | Papers | Citations |
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Mark E. Davis | 113 | 568 | 55334 |
Robert T. Jensen | 109 | 648 | 40107 |
Wayne W. Hancock | 103 | 505 | 35694 |
Gary K. Steinberg | 94 | 529 | 31259 |
John H. Zhang | 84 | 895 | 29976 |
Vinod H. Thourani | 81 | 544 | 38900 |
Samuel W. French | 80 | 570 | 22757 |
Michael P. Marks | 76 | 288 | 25574 |
Ajit P. Yoganathan | 74 | 626 | 21612 |
Peter Vajkoczy | 73 | 564 | 22423 |
Dennis P. Orgill | 70 | 412 | 20440 |
Sidney Wallace | 70 | 395 | 17877 |
Raul Coimbra | 67 | 447 | 15563 |
E. Mark Haacke | 63 | 343 | 17830 |
Stephen Ashwal | 62 | 223 | 16337 |