D
Dongsheng Duan
Researcher at University of Missouri
Publications - 226
Citations - 13194
Dongsheng Duan is an academic researcher from University of Missouri. The author has contributed to research in topics: Duchenne muscular dystrophy & Dystrophin. The author has an hindex of 57, co-authored 207 publications receiving 11389 citations. Previous affiliations of Dongsheng Duan include University of Southern California & University of Pennsylvania.
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In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.
Christopher E. Nelson,Chady H. Hakim,David G. Ousterout,Pratiksha I. Thakore,Eirik A. Moreb,Ruth M. Castellanos Rivera,Sarina Madhavan,Xiufang Pan,F. Ann Ran,F. Ann Ran,Winston X. Yan,Winston X. Yan,Winston X. Yan,Aravind Asokan,Feng Zhang,Dongsheng Duan,Charles A. Gersbach +16 more
TL;DR: In this paper, an adeno-associated virus was used to deliver the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system to the mdx mouse model of Duchenne muscular dystrophy (DMD) to remove the mutated exon 23 from the dystrophin gene.
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
Christopher E. Nelson,Chady H. Hakim,David G. Ousterout,Pratiksha I. Thakore,Eirik A. Moreb,Ruth M. Castellanos Rivera,Sarina Madhavan,X. Pan,F. A. Ran,Winston X. Yan,Aravind Asokan,Feng Zhang,Dongsheng Duan,Charles A. Gersbach +13 more
TL;DR: This work establishes CRISPR-Cas9–based genome editing as a potential therapy to treat DMD and partially restored dystrophin protein expression in skeletal and cardiac muscle and improved skeletal muscle function.
Journal ArticleDOI
Modular flexibility of dystrophin: Implications for gene therapy of Duchenne muscular dystrophy
Scott Q. Harper,Michael A. Hauser,Michael A. Hauser,Christiana DelloRusso,Christiana DelloRusso,Dongsheng Duan,Robert W. Crawford,Stephanie F. Phelps,Hollie Harper,Ann S. Robinson,John F. Engelhardt,Susan V. Brooks,Jeffrey S. Chamberlain,Jeffrey S. Chamberlain +13 more
TL;DR: It is shown that injection of adeno-associated viruses carrying micro-dystrophins into dystrophic muscles of immunocompetent mdx mice results in a striking reversal of histopathological features of this disease.
Journal ArticleDOI
Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue
Dongsheng Duan,Prerna Sharma,Jusan Yang,Yongping Yue,Lorita Dudus,Yulong Zhang,Krishna J. Fisher,John F. Engelhardt +7 more
TL;DR: These studies suggest that certain structural characteristics of AAV circular intermediates may explain long-term episomal persistence with this vector and aid in the development of nonviral gene delivery systems with increased efficiency.
Journal ArticleDOI
Animal models of Duchenne muscular dystrophy: From basic mechanisms to gene therapy
TL;DR: The field has reached the stage at which the results in mdx mice can be validated and scaled-up in symptomatic large animals, and the canine DMD (cDMD) model will be excellent for these studies.