A
Aravind Asokan
Researcher at Duke University
Publications - 144
Citations - 9104
Aravind Asokan is an academic researcher from Duke University. The author has contributed to research in topics: Adeno-associated virus & Transduction (genetics). The author has an hindex of 40, co-authored 127 publications receiving 7401 citations. Previous affiliations of Aravind Asokan include University of Alabama at Birmingham & University of North Carolina at Chapel Hill.
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In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.
Christopher E. Nelson,Chady H. Hakim,David G. Ousterout,Pratiksha I. Thakore,Eirik A. Moreb,Ruth M. Castellanos Rivera,Sarina Madhavan,Xiufang Pan,F. Ann Ran,F. Ann Ran,Winston X. Yan,Winston X. Yan,Winston X. Yan,Aravind Asokan,Feng Zhang,Dongsheng Duan,Charles A. Gersbach +16 more
TL;DR: In this paper, an adeno-associated virus was used to deliver the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system to the mdx mouse model of Duchenne muscular dystrophy (DMD) to remove the mutated exon 23 from the dystrophin gene.
In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
Christopher E. Nelson,Chady H. Hakim,David G. Ousterout,Pratiksha I. Thakore,Eirik A. Moreb,Ruth M. Castellanos Rivera,Sarina Madhavan,X. Pan,F. A. Ran,Winston X. Yan,Aravind Asokan,Feng Zhang,Dongsheng Duan,Charles A. Gersbach +13 more
TL;DR: This work establishes CRISPR-Cas9–based genome editing as a potential therapy to treat DMD and partially restored dystrophin protein expression in skeletal and cardiac muscle and improved skeletal muscle function.
Journal ArticleDOI
Adeno-associated virus serotypes: vector toolkit for human gene therapy.
TL;DR: This review is focused on recent developments in the isolation of novel AAV serotypes and isolates, their production and purification, diverse tissue tropisms, mechanisms of cellular entry/trafficking, and capsid structure.
Journal ArticleDOI
The AAV Vector Toolkit: Poised at the Clinical Crossroads
TL;DR: The discovery of naturally occurring adeno-associated virus isolates in different animal species and the generation of engineered AAV strains using molecular genetics tools have yielded a versatile AAV vector toolkit and a battery of second generation AAV vectors are now available.
Journal ArticleDOI
Aquaporin-4-dependent glymphatic solute transport in the rodent brain.
Humberto Mestre,Lauren M. Hablitz,Anna L.R. Xavier,Weixi Feng,Wenyan Zou,Tinglin Pu,Hiromu Monai,Giridhar Murlidharan,Ruth M. Castellanos Rivera,Matthew J. Simon,Martin M. Pike,Virginia Plá,Ting Du,Benjamin T. Kress,Xiaowen Wang,Benjamin A. Plog,Alexander S. Thrane,Alexander S. Thrane,Iben Lundgaard,Iben Lundgaard,Yoichiro Abe,Masato Yasui,John H. Thomas,Ming Xiao,Hajime Hirase,Aravind Asokan,Aravind Asokan,Jeffrey J. Iliff +27 more
TL;DR: It is concur that CSF influx is higher in wild-type mice than in four different Aqp4 KO lines and in one line that lacks perivascular AQP4 (Snta1 KO), and it is reported that intrastriatal injections suppress glymphatic function.