D
Donna F. Christner
Researcher at University of Maryland, College Park
Publications - 7
Citations - 358
Donna F. Christner is an academic researcher from University of Maryland, College Park. The author has contributed to research in topics: Cleavage (embryo) & DNA. The author has an hindex of 6, co-authored 7 publications receiving 354 citations.
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Journal ArticleDOI
Sequence-specific isotope effects on the cleavage of DNA by bleomycin
John W. Kozarich,Leroy Worth,Bruce L. Frank,Donna F. Christner,Dana E. Vanderwall,JoAnne Stubbe +5 more
TL;DR: Primary kinetic isotope effects have been directly observed at individual thymidine residues with DNA sequencing technology, and the chemistry of DNA damage has been proposed to involve rate-limiting abstraction of the 4'-hydrogen.
Journal ArticleDOI
Isotope effects on the cleavage of DNA by bleomycin: mechanism and modulation.
Leroy Worth,Bruce L. Frank,Donna F. Christner,Michael J. Absalon,JoAnne Stubbe,John W. Kozarich +5 more
TL;DR: The findings suggest that the kinetics, thermodynamics, and geometry of carbon-hydrogen bond cleavage by Fe.BLM permit the observation of large isotope effects on this chemical step, and that it may be viewed, therefore, as a special case.
Journal ArticleDOI
Isotope effects on the sequence-specific cleavage of DNA by neocarzinostatin: kinetic partitioning between 4'- and 5'-hydrogen abstraction at unique thymidine sites
Bruce L. Frank,Leroy Worth,Donna F. Christner,John W. Kozarich,JoAnne Stubbe,Lizzy S. Kappen,Irving H. Goldberg +6 more
Journal ArticleDOI
Unmasking the chemistry of DNA cleavage by the esperamicins : modulation of 4'-hydrogen abstraction and bistranded damage by the fucose-anthranilate moiety
Donna F. Christner,Bruce L. Frank,John W. Kozarich,JoAnne Stubbe,Jerzy Golik,Terrence W. Doyle,Ira E. Rosenberg,Bala Krishnan +7 more
TL;DR: The chemistry of DNA cleavage by esperamicins A 1, C, D, and E (ep A, C-E) has been examined in this article, where high-resolution gel electrophoresis reveals that esp A, a known single-strand cleaver, affords fragmentation products consistent with exclusive 5'-hydrogen abstraction.
Journal ArticleDOI
Neocarzinostatin-induced hydrogen atom abstraction from C-4' and C-5' of the T residue at a d(GT) step in oligonucleotides: shuttling between deoxyribose attack sites based on isotope selection effects.
Lizzy S. Kappen,Irving H. Goldberg,Bruce L. Frank,Leroy Worth,Donna F. Christner,John W. Kozarich,JoAnne Stubbe +6 more
TL;DR: The thiol-activated neocarzinostatin chromophore cleaves duplex oligonucleotides containing the sequence-TGTTTGA-, indicating the involvement of 4'- as well as 5'-chemistry at this residue, and the internal partitioning between them is influenced by thiols.