Max Shapiro

TL;DR: Results demonstrate that noncytopathic antiviral mechanisms contribute to viral clearance during acute viral hepatitis by purging HBV replicative intermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected cells.

TL;DR: It is shown that the hypervariable region 1 (HVR1) of the envelope 2 (E2) protein is a critical neutralization domain of hepatitis C virus and can elicit protective immunity.

TL;DR: The results suggested that swine HEV may infect humans, and in a reciprocal experiment, specific-pathogen-free pigs were experimentally infected with the US-2 strain of human HEV that is genetically similar to swineHEV.

TL;DR: Experimental evidence in vivo that HCV infection elicits a neutralizing antibody response in humans is provided but it is suggested that such antibodies are isolate-specific, raising concerns for the development of a broadly reactive vaccine against HCV.

TL;DR: It is demonstrated that mutations that are adaptive for replication of HCV in cell culture may be highly attenuating in vivo, and that chimpanzees infected with RNA transcripts of a Con1 genome containing the three adaptive mutations failed to achieve active HCV infection.