R
Ronald E. Engle
Researcher at National Institutes of Health
Publications - 97
Citations - 9824
Ronald E. Engle is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Hepatitis B virus. The author has an hindex of 47, co-authored 96 publications receiving 9226 citations. Previous affiliations of Ronald E. Engle include Georgetown University & Georgetown University Medical Center.
Papers
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Journal ArticleDOI
Lack of protective immunity against reinfection with hepatitis C virus
Patrizia Farci,Harvey J. Alter,Sugantha Govindarajan,Doris C. Wong,Ronald E. Engle,Richard R. Lesniewski,Isa K. Mushahwar,Suresh M. Desai,Roger H. Miller,Norio Ogata,Robert H. Purcell +10 more
TL;DR: Evidence indicates that HCV infection does not elicit protective immunity against reinfection with homologous or heterologous strains, which raises concerns for the development of effective vaccines against HCV.
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Prevalence of Antibodies to Hepatitis E Virus in Veterinarians Working with Swine and in Normal Blood Donors in the United States and Other Countries
Xiang-Jin Meng,Barry Wiseman,François Elvinger,D. K. Guenette,Thomas E. Toth,Ronald E. Engle,Suzanne U. Emerson,Robert H. Purcell +7 more
TL;DR: There was a difference in anti- HEV prevalence in both swine veterinarians and blood donors among the eight selected states, with subjects from Minnesota six times more likely to be anti-HEV positive than those from Alabama, and age was not a factor in the observed differences.
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Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization.
Patrizia Farci,Harvey J. Alter,Doris C. Wong,Roger H. Miller,Sugantha Govindarajan,Ronald E. Engle,Max Shapiro,Robert H. Purcell +7 more
TL;DR: Experimental evidence in vivo that HCV infection elicits a neutralizing antibody response in humans is provided but it is suggested that such antibodies are isolate-specific, raising concerns for the development of a broadly reactive vaccine against HCV.
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Monoclonal antibody-mediated enhancement of dengue virus infection in vitro and in vivo and strategies for prevention
TL;DR: It is confirmed that significant viral amplification could occur during DENV infections in humans with prior infection or with maternally transferred immunity, possibly leading to severe dengue.
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A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species.
TL;DR: DNase treatment of serum samples may prove to be a very useful tool for virus discovery and the DNase-SISPA method is suitable for screening of a large number of samples and also enables rapid sequence determination of high-titer viruses.