Ilan Stein

TL;DR: It is shown that the inflammatory process triggers hepatocyte NF-κB through upregulation of tumour-necrosis factor-α (TNFα) in adjacent endothelial and inflammatory cells, and is therefore a potential target for cancer prevention in chronic inflammatory diseases.

TL;DR: Using bicistronic reporter gene constructs, it is shown that the 1,014-bp 5′UTR of VEGF contains a functional internal ribosome entry site (IRES), thereby securing efficient production of V EGF even under unfavorable stress conditions.

TL;DR: Two different consequences of tissue ischemia, namely, hypoxia and glucose deprivation, induce VEGF and GLUT-1 expression by similar mechanisms, which function, in turn, to satisfy the tissue needs through expanding its vasculature and improving its glucose utilization, respectively.

TL;DR: It is found that hepatic ELSs indicated poor prognosis for hepatocellular carcinoma (HCC), and they constituted immunopathological microniches wherein malignant hepatocyte progenitor cells appeared and thrived in a complex cellular and cytokine milieu until gaining self-sufficiency.

TL;DR: The analysis of melanoma patient tumor data recapitulates the results in terms of overall survival and response to immune checkpoint therapy and highlights the importance of clonal mutations in robust immune surveillance and the need to quantify patient ITH to determine the response to checkpoint blockade.