Dorothee Nashan

TL;DR: This study identified a deregulated gene network centered around microphthalmia-associated transcription factor, a transcription factor known to play a key role in melanoma development, and define miRNAs and miRNA target genes that offer candidate biomarkers in human melanoma.

TL;DR: The findings reveal that the miR-29a/b1 cluster is to be included in the group of IFN- and STAT-regulated genes and may act as effectors of cytokine signalling in melanoma and other cancer cells as well as in the immune system.

TL;DR: There is strong evidence that levels of cell-free miRNAs only change significantly at later stages of melanoma progression, which has serious implications for miRNA biomarker studies in cancer.

TL;DR: This is the first report demonstrating the functional involvement of EVs in melanoma drug resistance by transporting a truncated but functional form of ALK, able to activate the MAPK signalling pathway in target cells.

TL;DR: A method that can overcome technical biases, predict clinically relevant outcomes and identify tumour-related biological processes in patients using previously collected large discovery datasets, and provides the prognosis of patient survival is presented.