A
Arnaud Muller
Researcher at University of Luxembourg
Publications - 46
Citations - 3670
Arnaud Muller is an academic researcher from University of Luxembourg. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 20, co-authored 40 publications receiving 2618 citations. Previous affiliations of Arnaud Muller include Laboratory of Molecular Biology.
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Journal ArticleDOI
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
Mahesh Desai,Mahesh Desai,Anna M. Seekatz,Nicole M. Koropatkin,Nobuhiko Kamada,Christina A. Hickey,Mathis Wolter,Nicholas A. Pudlo,Sho Kitamoto,Nicolas Terrapon,Arnaud Muller,Vincent B. Young,Bernard Henrissat,Paul Wilmes,Thaddeus S. Stappenbeck,Gabriel Núñez,Eric C. Martens +16 more
TL;DR: Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium.
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Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment.
Anna Dirkse,Anna Golebiewska,Thomas Buder,Thomas Buder,Petr V. Nazarov,Arnaud Muller,Suresh Poovathingal,Nicolaas H. C. Brons,Sonia Leite,Nicolas Sauvageot,Dzjemma Sarkisjan,Mathieu Seyfrid,Sabrina Fritah,Daniel Stieber,Alesandro Michelucci,Frank Hertel,Christel Herold-Mende,Francisco Azuaje,Alexander Skupin,Rolf Bjerkvig,Andreas Deutsch,Anja Voss-Böhme,Anja Voss-Böhme,Simone P. Niclou +23 more
TL;DR: It is reported that cells expressing CSC-associated cell membrane markers in Glioblastoma do not represent a clonal entity defined by distinct functional properties and transcriptomic profiles, but rather a plastic state that most cancer cells can adopt.
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Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Demetra Philippidou,Martina Schmitt,Dirk Moser,Christiane Margue,Petr V. Nazarov,Arnaud Muller,Laurent Vallar,Dorothee Nashan,Iris Behrmann,Stephanie Kreis +9 more
TL;DR: This study identified a deregulated gene network centered around microphthalmia-associated transcription factor, a transcription factor known to play a key role in melanoma development, and define miRNAs and miRNA target genes that offer candidate biomarkers in human melanoma.
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Neurodegeneration by Activation of the Microglial Complement–Phagosome Pathway
Liviu-Gabriel Bodea,Yiner Wang,Bettina Linnartz-Gerlach,Jens Kopatz,Lasse Sinkkonen,Ruth E. Musgrove,Tony Kaoma,Arnaud Muller,Laurent Vallar,Donato A. Di Monte,Rudi Balling,Harald Neumann +11 more
TL;DR: It is demonstrated in vivo that repeated systemic challenge of mice over four consecutive days with bacterial LPS maintained an elevated microglial inflammatory phenotype and induced loss of dopaminergic neurons in the substantia nigra, confirming the involvement of the complement system in neurodegeneration.
Journal ArticleDOI
Interplay of microRNAs, transcription factors and target genes: linking dynamic expression changes to function
Petr V. Nazarov,Susanne E. Reinsbach,Arnaud Muller,Nathalie Nicot,Demetra Philippidou,Laurent Vallar,Stephanie Kreis +6 more
TL;DR: This work investigates simultaneously the transcriptional changes of miRNA and mRNA expression levels over time after activation of the Janus kinase/Signal transducer and activator of transcription (Jak/STAT) pathway by interferon-γ stimulation of melanoma cells and demonstrates the dynamic interplay of miRNAs and upstream regulators with biological functions.