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Douglas L. Miller
Researcher at University of Vermont
Publications - 34
Citations - 1111
Douglas L. Miller is an academic researcher from University of Vermont. The author has contributed to research in topics: Bubble & Cavitation. The author has an hindex of 20, co-authored 34 publications receiving 1094 citations. Previous affiliations of Douglas L. Miller include University of Michigan.
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Journal ArticleDOI
Sonoporation of monolayer cells by diagnostic ultrasound activation of contrast-agent gas bodies.
Douglas L. Miller,Jawaid Quddus +1 more
TL;DR: Diagnostic US activation of contrast-agent gas bodies can produce cell membrane damage, and the effect was only weakly dependent on pulse-repetition frequency or exposure duration, but was strongly dependent on contrast agent concentration below 2%.
Journal ArticleDOI
Platelet aggregation induced by ultrasound under specialized conditions in vitro
TL;DR: Human platelets were induced by 2.1-megahertz ultrasound to form aggregates around gas-filled pores in membranes immersed in platelet-rich plasma, and ultrasound generated by a medical Doppler device, whose intensity exceeded this, induced aggregate formation under the same conditions.
Journal ArticleDOI
Stable cavitation at low ultrasonic intensities induces cell death and inhibits 3H-TdR incorporation by Con-A-stimulated murine lymphocytes in vitro.
TL;DR: Murine spleen cell suspensions stimulated by Concanavalin A were exposed to 1.6-MHz continuous-wave ultrasound at low intensities in the presence of a Nuclepore membrane that contained stabilized gas bodies and induced cell lysis and reduced the fraction of intact cells that excluded trypan blue.
Journal ArticleDOI
A search for ultrasonic cavitation within the canine cardiovascular system
TL;DR: This in vivo system was designed to assess the potential for cavitation bioeffects and the essentially negative results obtained may limit the expected or potential risk of this mechanism in regard to medical applications of ultrasound.
Journal ArticleDOI
Microstreaming shear as a mechanism of cell death in Elodea leaves exposed to ultrasound
TL;DR: Membrane damage induced by microstreaming shear stress appears to be a plausible mechanism of cell death in Elodea, and a valuable unifying concept for consideration of bioeffects of ultrasonic cavitation.