D
Douglas S. Robinson
Researcher at University College Hospital
Publications - 158
Citations - 22877
Douglas S. Robinson is an academic researcher from University College Hospital. The author has contributed to research in topics: Eosinophil & Asthma. The author has an hindex of 69, co-authored 155 publications receiving 22056 citations. Previous affiliations of Douglas S. Robinson include National Institutes of Health & Medical Research Council.
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Journal ArticleDOI
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
Douglas S. Robinson,Qutayba Hamid,Sun Ying,Anne Tsicopoulos,J. Barkans,Andrew Bentley,Christopher Corrigan,Stephen R. Durham,A. B. Kay +8 more
TL;DR: Atopic asthma is associated with activation in the bronchi of the interleukin-3, 4, and 5 and GM-CSF gene cluster, a pattern compatible with predominant activation of the TH2-like T-cell population.
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Eosinophil's Role Remains Uncertain as Anti–Interleukin-5 only Partially Depletes Numbers in Asthmatic Airway
TL;DR: Anti-IL-5 treatment reduces but does not deplete airway or bone marrow eosinophils and their products, and there were no significant changes in clinical measures of asthma between the mepolizumab and placebo-treated groups.
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Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.
Sun Ying,Brian J. O'Connor,Jonathan Ratoff,Qiu Meng,K. Mallett,David J. Cousins,Douglas S. Robinson,Guizhen Zhang,Jisheng Zhao,Tak H. Lee,Christopher Corrigan +10 more
TL;DR: The data implicate TSLP, TARC/ CCL17, MDC/CCL22, and IP-10/CXCL10 in asthma pathogenesis, which may act partly through selective development and retention, or recruitment of Th2 cells bearing their receptors.
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Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
P. Flood-Page,Andrew Menzies-Gow,Simon Phipps,Sun Ying,A. Wangoo,Mara S. Ludwig,Neil Barnes,Douglas S. Robinson,A. Barry Kay +8 more
TL;DR: Treating asthmatics with anti-IL-5 antibody, which specifically decreased airway eosinophil numbers, significantly reduced the expression of tenascin, lumican, and procollagen III in the bronchial mucosal RBM when compared with placebo.
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Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease.
Eleanor M. Ling,Eleanor M. Ling,Trevor Smith,X. Dao Nguyen,Carol Pridgeon,Margaret J. Dallman,Justine Arbery,Victoria A. Carr,Douglas S. Robinson,Douglas S. Robinson +9 more
TL;DR: Treatment to enhance regulatory T-cell responses, in concert with reduction of Th2 cell activation, might be useful in prevention and treatment of allergic disease.