D
David J. Cousins
Researcher at University of Leicester
Publications - 66
Citations - 4061
David J. Cousins is an academic researcher from University of Leicester. The author has contributed to research in topics: Cytokine & Innate lymphoid cell. The author has an hindex of 28, co-authored 65 publications receiving 3604 citations. Previous affiliations of David J. Cousins include Medical Research Council & King University.
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Journal ArticleDOI
Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.
Sun Ying,Brian J. O'Connor,Jonathan Ratoff,Qiu Meng,K. Mallett,David J. Cousins,Douglas S. Robinson,Guizhen Zhang,Jisheng Zhao,Tak H. Lee,Christopher Corrigan +10 more
TL;DR: The data implicate TSLP, TARC/ CCL17, MDC/CCL22, and IP-10/CXCL10 in asthma pathogenesis, which may act partly through selective development and retention, or recruitment of Th2 cells bearing their receptors.
Journal ArticleDOI
IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo
David A. Jackson,David A. Jackson,Heidi Makrinioti,Batika M. J. Rana,Betty Shamji,Maria-Belen Trujillo-Torralbo,Maria-Belen Trujillo-Torralbo,Joseph Footitt,Joseph Footitt,Jerico del-Rosario,Jerico del-Rosario,Aurica G. Telcian,A A Nikonova,Jie Zhu,Julia Aniscenko,Leila Gogsadze,Eteri Bakhsoliani,Stephanie Traub,Jaideep Dhariwal,Jaideep Dhariwal,James D. Porter,Duncan Hunt,Toby Hunt,Trevor Hunt,Luminita A. Stanciu,Musa Khaitov,Nathan W. Bartlett,Michael R. Edwards,Onn Min Kon,Patrick Mallia,Patrick Mallia,Nikolaos G. Papadopoulos,Cezmi A. Akdis,John Westwick,Matthew J. Edwards,David J. Cousins,Ross P. Walton,Sebastian L. Johnston,Sebastian L. Johnston +38 more
TL;DR: IL-33 and type 2 cytokines are induced during a rhinovirus-induced asthma exacerbation in vivo and relate to exacerbation severity, which is a novel therapeutic approach for asthma exacerbations.
Journal ArticleDOI
Expression and Cellular Provenance of Thymic Stromal Lymphopoietin and Chemokines in Patients with Severe Asthma and Chronic Obstructive Pulmonary Disease
Sun Ying,Brian J. O'Connor,Jonathan Ratoff,Qiu Meng,Cailong Fang,David J. Cousins,Guizhen Zhang,Shuyan Gu,Zhongli Gao,Betty Shamji,Matthew J. Edwards,Tak H. Lee,Christopher Corrigan +12 more
TL;DR: It is hypothesized that there is distinct airways expression of TSLP and chemokines which preferentially attract Th1- and Th2-type T cells, and influx of T cells bearing their receptors in asthma and COPD.
Journal ArticleDOI
Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation
Janine Beale,Janine Beale,Janine Beale,Annabelle Jayaraman,Annabelle Jayaraman,Annabelle Jayaraman,David A. Jackson,Jonathan Macintyre,Michael R. Edwards,Michael R. Edwards,Ross P. Walton,Ross P. Walton,Ross P. Walton,Jie Zhu,Jie Zhu,Jie Zhu,Yee Man Ching,Yee Man Ching,Yee Man Ching,Betty Shamji,Matthew J. Edwards,John Westwick,David J. Cousins,David J. Cousins,You Yi Hwang,Andrew N. J. McKenzie,Sebastian L. Johnston,Nathan W. Bartlett,Nathan W. Bartlett,Nathan W. Bartlett +29 more
TL;DR: Asthmatic epithelial cells have an increased intrinsic capacity for expression of a pro–type 2 cytokine in response to a viral infection, and IL-25 is a key mediator of RV-induced exacerbations of pulmonary inflammation.
Journal ArticleDOI
Ligation of TLR9 induced on human IL-10–secreting Tregs by 1α,25-dihydroxyvitamin D3 abrogates regulatory function
Zoe Urry,Emmanuel Xystrakis,David F. Richards,Joanne McDonald,Zahid Sattar,David J. Cousins,Christopher Corrigan,Emma Hickman,Zarin Brown,Catherine M. Hawrylowicz +9 more
TL;DR: It is shown that TLR9 is highly expressed by human Treg secreting the antiinflammatory cytokine IL-10 induced following stimulation of blood and tissue CD3+ T cells in the presence of 1alpha,25-dihydroxyvitamin D3 (1alpha25VitD3), the active form of Vitamin D, with or without the glucocorticoid dexamethasone.