D
Dwight Macdonald
Researcher at Merck & Co.
Publications - 61
Citations - 1338
Dwight Macdonald is an academic researcher from Merck & Co.. The author has contributed to research in topics: Renin inhibitor & Indole test. The author has an hindex of 20, co-authored 59 publications receiving 1281 citations.
Papers
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Journal ArticleDOI
Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis
Annette Robichaud,Panagiota B. Stamatiou,S.-L. Catherine Jin,Nicholas Lachance,Dwight Macdonald,Susana Liu,Zheng Huang,Marco Conti,Chi-Chung Chan +8 more
TL;DR: Findings strongly support the hypothesis that inhibition of PDE4D is pivotal to the anesthesia-reversing effect of PMNPQ and is likely responsible for emesis induced by PDE 4 inhibitors.
Journal ArticleDOI
The next generation of PDE4 inhibitors.
TL;DR: A number of highly potent PDE4 inhibitors are being developed for the treatment of asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis and Crohn's disease.
Patent
8-(biaryl) quinoline pde4 inhibitors
Denis Deschenes,Daniel Dube,Dube Laurence,Gallant Michel,Girard Yves,Lacombe Patrick,Dwight Macdonald +6 more
TL;DR: In this article, a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of phosphodiesterase-4 inhibitor was proposed, which can enhance memory, learning, retention, recall, awareness and judgement in health subjects.
Patent
Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
Denis Deschenes,Daniel Dube,Michel Gallant,Yves Girard,Patrick Lacombe,Dwight Macdonald,Anthony Mastracchio,Helene Perrier +7 more
TL;DR: Novel sulfuric acid, methane sulfonic acid, p-toluenesulfonic acid (PDE4), 2-naphthalenes, and benzenesulfonic acids are PDE4 inhibitors as discussed by the authors, where the aryl group at the 8 position contains a substituent substituted-alkenyl group.
Patent
Aryl furan derivatives as pde iv inhibitors
Helene Perrier,Yongxin Han,Christopher I. Bayly,Dwight Macdonald,Andre Giroux,Robert N. Young +5 more
TL;DR: In this article, a compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV).