D
Dylan Carney
Researcher at University of California, San Francisco
Publications - 7
Citations - 1838
Dylan Carney is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Histone H3 & Histone methyltransferase. The author has an hindex of 6, co-authored 7 publications receiving 1746 citations. Previous affiliations of Dylan Carney include Stanford University & Harvard University.
Papers
More filters
Journal ArticleDOI
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression
Xiaobing Shi,Tao Hong,Kay L. Walter,Mark D. Ewalt,Eriko Michishita,Tiffany Hung,Dylan Carney,Pedro V. Peña,Fei Lan,Mohan R. Kaadige,Nicolas Lacoste,Christelle Cayrou,Foteini Davrazou,Anjanabha Saha,Bradley R. Cairns,Donald E. Ayer,Tatiana G. Kutateladze,Yang Shi,Jacques Côté,Katrin F. Chua,Katrin F. Chua,Or Gozani +21 more
TL;DR: A novel class of methylated H3K4 effector domains—the PHD domains of the ING (for inhibitor of growth) family of tumour suppressor proteins—are identified and established a pivotal role for trimethylation of H 3K4 in gene repression and, potentially, tumour suppressing mechanisms.
Journal ArticleDOI
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination
Adam G. W. Matthews,Alex J. Kuo,Santiago Ramón-Maiques,Sunmi Han,Karen S. Champagne,Dmitri N. Ivanov,Mercedes Gallardo,Dylan Carney,Peggie Cheung,David N. Ciccone,Kay L. Walter,Paul J. Utz,Yang Shi,Tatiana G. Kutateladze,Wei Yang,Or Gozani,Marjorie A. Oettinger +16 more
TL;DR: In this article, a plant homeodomain (PHD) finger bound to histone H3 trimethylated at lysine 4 (H3K4me3) was found to be essential for the recognition of histone methylation in mammalian DNA recombination.
Journal ArticleDOI
The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2
Santiago Ramón-Maiques,Alex J. Kuo,Dylan Carney,Adam G. W. Matthews,Marjorie A. Oettinger,Or Gozani,Wei Yang +6 more
TL;DR: This work provides a molecular basis for chromatin-dependent gene recombination and presents a single protein domain that simultaneously recognizes two distinct hist one modifications, revealing added complexity in the read-out of combinatorial histone modifications.
Journal ArticleDOI
Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.
Andrew S. Koh,Alex J. Kuo,Sang Youn Park,Peggie Cheung,Jakub Abramson,Dennis J. Bua,Dylan Carney,Steven E. Shoelson,Or Gozani,Robert E. Kingston,Christophe Benoist,Diane Mathis +11 more
TL;DR: Aire's activity as a histone-binding module mediates the thymic display of PTAs that promotes self-tolerance and prevents organ-specific autoimmunity.
Journal ArticleDOI
A Top-Five List for Emergency Medicine: A Pilot Project to Improve the Value of Emergency Care
Jeremiah D. Schuur,Jeremiah D. Schuur,Dylan Carney,Everett T. Lyn,Ali S. Raja,Ali S. Raja,John A. Michael,Nicholas G. Ross,Arjun K. Venkatesh +8 more
TL;DR: A technical expert panel (TEP) is assembled and conducted a modified Delphi process to identify clinical actions that are of low value and within the control of ED health care providers and can be used to identify additional actionable targets of overuse in emergency medicine.