D
David N. Ciccone
Researcher at Harvard University
Publications - 14
Citations - 2136
David N. Ciccone is an academic researcher from Harvard University. The author has contributed to research in topics: Chromatin & Immune system. The author has an hindex of 7, co-authored 10 publications receiving 2078 citations. Previous affiliations of David N. Ciccone include Howard Hughes Medical Institute & Boston University.
Papers
More filters
Journal ArticleDOI
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
Craig H. Bassing,Katrin F. Chua,JoAnn Sekiguchi,Heikyung Suh,Scott Whitlow,James Fleming,Brianna C. Monroe,David N. Ciccone,Catherine T. Yan,Katerina Vlasakova,David M. Livingston,David O. Ferguson,Ralph Scully,Frederick W. Alt +13 more
TL;DR: It is shown that H2AX function is essential for mammalian DNA repair and genomic stability, and not required for NHEJ per se.
Journal ArticleDOI
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.
Xiaohua Wu,Velvizhi Ranganathan,David S. Weisman,Walter F. Heine,David N. Ciccone,Ted O’Neill,Ted O’Neill,Kindra E. Crick,Kerry A. Pierce,William S. Lane,Gary Rathbun,Gary Rathbun,David M. Livingston,David T. Weaver +13 more
TL;DR: It is reported that Nbs is specifically phosphorylated in response to γ-radiation, ultraviolet light and exposure to hydroxyurea, and phosphorylation of Nbs by Atm is critical for certain responses of human cells to DNA damage.
Journal ArticleDOI
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination
Adam G. W. Matthews,Alex J. Kuo,Santiago Ramón-Maiques,Sunmi Han,Karen S. Champagne,Dmitri N. Ivanov,Mercedes Gallardo,Dylan Carney,Peggie Cheung,David N. Ciccone,Kay L. Walter,Paul J. Utz,Yang Shi,Tatiana G. Kutateladze,Wei Yang,Or Gozani,Marjorie A. Oettinger +16 more
TL;DR: In this article, a plant homeodomain (PHD) finger bound to histone H3 trimethylated at lysine 4 (H3K4me3) was found to be essential for the recognition of histone methylation in mammalian DNA recombination.
Journal ArticleDOI
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: A potential mechanism for position-effect variegation
TL;DR: It is shown that the level of H3-K79 methylation is low at all Sir-dependent silenced loci but not at other transcriptionally repressed regions, and that silencing proteins block the ability of Dot1 to methylate histone H3.
Journal ArticleDOI
Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4
TL;DR: It is suggested that the hotspots of di-Me H3-K4 are important marks for locus accessibility, which imply that the regulation of V(D)J recombination involves recruitment of specific methyltransferases in a localized manner.