E
E. Andreas Larsson
Researcher at Stockholm University
Publications - 10
Citations - 1549
E. Andreas Larsson is an academic researcher from Stockholm University. The author has contributed to research in topics: Bacterial polysaccharide & Nuclear magnetic resonance spectroscopy. The author has an hindex of 9, co-authored 10 publications receiving 1196 citations. Previous affiliations of E. Andreas Larsson include Carlsberg Laboratory & Nanyang Technological University.
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Journal ArticleDOI
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Daniel Martinez Molina,Rozbeh Jafari,Marina Ignatushchenko,Takahiro Seki,E. Andreas Larsson,Chen Dan,Lekshmy Sreekumar,Yihai Cao,Yihai Cao,Pär Nordlund,Pär Nordlund +10 more
TL;DR: This cellular thermal shift assay (CETSA) is based on the biophysical principle of ligand-induced thermal stabilization of target proteins and validated drug binding for a set of important clinical targets and monitored processes of drug transport and activation, off-target effects and drug resistance in cancer cell lines, as well as drug distribution in tissues.
Journal ArticleDOI
Fragment-based ligand design of novel potent inhibitors of tankyrases.
E. Andreas Larsson,Anna Elisabet Jansson,Fui Mee Ng,Siew Wen Then,Resmi Panicker,Boping Liu,Kanda Sangthongpitag,Vishal Pendharkar,Shi Jing Tai,Jeffrey Hill,Chen Dan,Soo Yei Ho,Wei Wen Cheong,Anders Poulsen,Stéphanie Blanchard,Grace Lin,Jenefer Alam,Thomas H. Keller,Pär Nordlund,Pär Nordlund +19 more
TL;DR: A structure- and biophysics-driven fragment-based ligand design strategy is applied to discover a novel family of potent inhibitors for human tankyrases, yielding compounds with affinities and IC50 values in the low nanomolar range and with good solubility, PARP selectivity, and ligand efficiency.
Journal ArticleDOI
Synthesis of reference standards to enable single cell metabolomic studies of tetramethylrhodamine-labeled ganglioside GM1
E. Andreas Larsson,Ulf Olsson,Colin D. Whitmore,Rita Martins,Guido Tettamanti,Ronald L. Schnaar,Norman J. Dovichi,Monica M. Palcic,Ole Hindsgaul +8 more
TL;DR: Ganglioside GM1 and its seven potential catabolic products were labeled with tetramethylrhodamine (TMR) to permit ultra-sensitive analysis using laser-induced fluorescence (LIF) detection.
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Yoctomole analysis of ganglioside metabolism in PC12 cellular homogenates.
Colin D. Whitmore,Ulf Olsson,E. Andreas Larsson,Ole Hindsgaul,Monica M. Palcic,Norman J. Dovichi +5 more
TL;DR: An ultrasensitive method based on migration of two components was employed andabolite that preserves the fluorescent label can be detected at the yoctomole level, which should allow characterization of this metabolic pathway in single cells.
Journal ArticleDOI
Determination of the Conformational Flexibility of Methyl α-Cellobioside in Solution by NMR Spectroscopy and Molecular Simulations
TL;DR: The conformational flexibility of methyl α-cellobioside in water and dimethyl sulfoxide solutions was investigated by 1D 1H,1H T-ROESY experiments as discussed by the authors.