J
Jeffrey Hill
Researcher at Agency for Science, Technology and Research
Publications - 90
Citations - 2730
Jeffrey Hill is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Protease & NS3. The author has an hindex of 26, co-authored 90 publications receiving 2389 citations. Previous affiliations of Jeffrey Hill include Cardiff University & University of Wales.
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Journal ArticleDOI
Wnt addiction of genetically defined cancers reversed by PORCN inhibition
Babita Madan,Zhiyuan Ke,Nathan Harmston,Soo Yei Ho,A O Frois,Jenefer Alam,Duraiswamy Athisayamani Jeyaraj,Vishal Pendharkar,Kakaly Ghosh,I H Virshup,Vithya Manoharan,Esther Hq Ong,Kanda Sangthongpitag,Jeffrey Hill,Enrico Petretto,Thomas H. Keller,May Ann Lee,Alex Matter,David M. Virshup,David M. Virshup +19 more
TL;DR: A novel potent, orally available PORCN inhibitor, ETC-1922159, that blocks the secretion and activity of all Wnts is developed that is remarkably effective in treating RSPO-translocation bearing colorectal cancer patient-derived xenografts.
Journal ArticleDOI
Molecular Cloning and Functional Characterization of MCH2, a Novel Human MCH Receptor
Jeffrey Hill,Malcolm Duckworth,Paul R. Murdock,Gillian I. Rennie,Cibele Sabido-David,Robert S. Ames,Philip G. Szekeres,Shelagh Wilson,Derk J. Bergsma,Israel S. Gloger,Dana S. Levy,Jon K. Chambers,Alison I. Muir +12 more
TL;DR: The cloning and functional characterization of a novel second human MCH receptor is described, initially identified in a genomic survey sequence as being homologous to MCH1 receptors, which belongs to class 1 of the G protein-coupled receptor superfamily.
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Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function
Sharon Xiaodai Lim,Tzuen Yih Saw,Min Zhang,Matthew R. Janes,Kassoum Nacro,Jeffrey Hill,An Qi Lim,Chia-Tien Chang,David A. Fruman,David A. Rizzieri,Soo Yong Tan,Hung Fan,Charles Chuah,Charles Chuah,S. Tiong Ong +14 more
TL;DR: This work shows that the MAP kinase interacting serine/threonine kinase (MNK)-eukaryotic translation initiation factor 4E (eIF4E) axis is overexpressed in BC GMPs but not normal HSCs, and suggests that pharmacologic inhibition of the MNK kinases may be therapeutically useful in BC chronic myeloid leukemia.
Journal ArticleDOI
High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum
TL;DR: DNA encoding the last 48 residues of the propart and the whole mature sequence of Plasmepsin II was inserted into the T7 dependent vector pET 3a and the ability of this enzyme to hydrolyse several chromogenic peptide substrates was examined.
Journal ArticleDOI
Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C).
Melanie J. Robbins,David Michalovich,Jeffrey Hill,Andrew R. Calver,Andrew D. Medhurst,Israel S. Gloger,M. Sims,Derek N. Middlemiss,Menelas N. Pangalos +8 more
TL;DR: Analysis of novel protein sequences identified containing seven putative transmembrane domains characteristic of G-protein-coupled receptors places them within the type 3 GPCR family, which includes metabotropic glutamate receptors, GABA(B) receptors, calcium-sensing receptors, and pheromone receptors.