The mortality rates for cirrhosis vary greatly from country to country. For example, in 1972 the World Health Organization reported mortality rates of 7.5/100,000 in Finland and 57.2/100,000 in France. The corresponding per-capita alcohol consumptions were 5.1 and 16.8 liters of absolute alcohol (International Statistics on Alcoholic Beverages: Production Trade and Consumption 1950–1972, 1977). Whereas deaths from other causes such as cardiovascular diseases decreased in the period from 1950 to 1974 by 2% in the United States, deaths from cirrhosis climbed 71.7%. Since then, mortality from cirrhosis has leveled off or even decreased in the United States. The reduction, however, pertains primarily to nonalcoholic cirrhosis (Liver Cirrhosis Mortality in the United States, 1988). In Canada, cirrhosis has been the most rapidly increasing cause of death in the population over 25 years of age, followed by lung and bronchial cancer and suicide (Schmidt, 1977), and it is now the fifth major cause of death for men in the productive years from 25 to 64 (Rankin, 1977). The concentration of mortality of alcoholic cirrhosis to a rather young population group also occurs in the United States. In Baltimore, it was the fifth leading cause of death for persons 25 to 44 years of age (Kuller et al., 1969) and the fourth leading cause of death for those 25 to 64 years of age in New York City (New York City; Summary of Vital Statistics, 1984).

Alcohol and the Liver

CIRRHOSIS of the liver, usually as a complication of alcoholism, is the third most frequent cause of death among those 25 to 64 years of age in urban areas such as New York City.1 This alcohol-indu...

Biochemical and Molecular Basis of Alcohol-Induced Injury to Liver and Other Tissues

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.510310201

Oxygen: modulator of metabolic zonation and disease of the liver.

https://www.journal-of-hepatology.eu/article/S0168-8278(00)80420-1/pdf

Alcoholic liver disease: new insights in pathogenesis lead to new treatments.

https://www.gastrojournal.org/article/0016-5085(90)91311-S/pdf

E. Baraona

Papers

Dependence of ethanol-induced redox shift on hepatic oxygen tensions prevailing in vivo.