E
E Nickbarg
Researcher at Children's Hospital of Philadelphia
Publications - 4
Citations - 1485
E Nickbarg is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Gene & XIST. The author has an hindex of 2, co-authored 2 publications receiving 1427 citations.
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Journal ArticleDOI
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.
A D'Andrea,M Rengaraju,Nicholas Valiante,Jihed Chehimi,M Kubin,M Aste,S H Chan,M Kobayashi,D Young,E Nickbarg +9 more
TL;DR: It is determined that most EBV-transformed human B lymphoblastoid cell lines constitutively produce low levels of the p70 heterodimer and an excess of the free p40 chain, whereas Burkitt lymphoma-derived, T, myeloid, and many solid tumor-derived cell lines produce neither.
Journal ArticleDOI
Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.
Jihed Chehimi,Stuart E. Starr,I Frank,M Rengaraju,Stephanie J. Jackson,C Llanes,M Kobayashi,B Perussia,D Young,E Nickbarg +9 more
TL;DR: The multiple biological effects of NKSF, its activity at very low molar concentrations, and its ability to synergize with other physiological stimuli suggest that NKSF/IL-12 is a lymphokine likely to have physiological importance and considerable therapeutic potential.
Journal ArticleDOI
Targeting Xist with compounds that disrupt RNA structure and X inactivation
Rodrigo Aguilar,Kerrie Spencer,Barry Kesner,Noreen F. Rizvi,Maulik D. Badmalia,Tyler Mrozowich,Jonathan D. Mortison,Carlos Rivera,Graham Smith,Julja Burchard,Peter J. Dandliker,Trushar R. Patel,E Nickbarg,Jeannie T. Lee +13 more
TL;DR: A screening strategy is devised and small molecules that bind the non-coding RNA prototype Xist are identified and the X1 compound has drug-like properties and binds specifically the RepA motif6 of Xist in vitro and in vivo.
Journal ArticleDOI
Targeting RNA with small molecules: lessons learned from Xist RNA
TL;DR: In this article , a screening strategy based upon affinity-selection mass spectrometry was devised to identify bioactive compounds for the non-coding RNA prototype, Xist, which has drug-like properties and binds specifically to the RepA motif.