Ebrahim Barkoudah

TL;DR: Recurrent MI or cardiac rupture accounts for a high proportion of sudden death in the early period after acute MI, whereas arrhythmic death may be more likely subsequently, helping explain the lack of benefit of early implantable cardioverter-defibrillator therapy.

TL;DR: Although the mortality rates were higher in RCTs with prior cardiovascular morbidity, the selection for chronic kidney disease—defined by either higher serum creatinine or lower estimated glomerular filtration rate and/or the presence of proteinuria—was associated with the highest mortality rates.

TL;DR: It is suggested that endothelium-derived NO stimulates guanylyl cyclase in vascular smooth muscle cells and, thereby, permits CO to cause dilation by activating K(Ca) channels.

TL;DR: The relative resistance of the renal renin response to acute and chronic renin–angiotensin system blockade supports the concept of an activated renal renIn–angiotsin system in diabetes, particularly at the level of the juxtaglomerular cell, and implies that diabetic patients might require higher doses of renin-angiotENSin system blockers to fully suppress the kidneys.

TL;DR: Internal Medicine Residency Program, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Department of Medicine, BrighamandWomen”s hospital and HarvardMedical School,Boston,MA, USA.